Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic-Ischemic Brain Injury Model in Newborn Rats.
| Autor: | Çolak R; Neonatal Intensive Care Unit, Division of Pediatric, Medical Park Bahcelievler Hospital, Altınbas University Medical Faculty, Istanbul, Turkey., Celik A; Department of Laboratory Animal Science, Faculty of Health Sciences, Dokuz Eylül University, Izmir, Turkey., Diniz G; Department of Pathology, Medical Faculty, Izmir Democracy University, Izmir, Turkey., Alkan Özdemir S; Neonatal Intensive Care Unit, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey., Yilmaz O; Department of Laboratory Animal Science, Faculty of Health Sciences, Dokuz Eylül University, Izmir, Turkey., Calkavur S; Neonatal Intensive Care Unit, Dr. Behçet Uz Children's Education and Research Hospital, Izmir, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of perinatology [Am J Perinatol] 2023 Apr; Vol. 40 (6), pp. 612-618. Date of Electronic Publication: 2021 May 27. |
| DOI: | 10.1055/s-0041-1730349 |
| Abstrakt: | Objective: This study aimed to evaluate the efficacy of Pycnogenol (PYC) and its antioxidant and antiapoptotic effect in an experimental hypoxic-ischemic (HI) rat model. Study Design: A total of 24 Wistar albino rats who were on the seventh postnatal day were divided into three groups with developed HI brain injury model under the sevoflurane anesthesia: 40 mg/kg PYC was given to Group A, saline was given to Group B, and the sham group was Group C. Neuronal apoptosis was investigated by terminal deoxynucleotidyl transferase dUTP nick end labeling and immunohistochemically stained manually with primer antibodies of tumor necrosis factor-α and interleukin-1β. Results: The neuronal cell injury was statistically lower in the PYC treatment group. Conclusion: This is the first study that investigates the role of PYC in the HI brain injury model. PYC reduces apoptosis and neuronal injury in the cerebral tissue of the rats. PYC may be a protective agent against hypoxic-ischemic encephalopathy. Key Points: · This is the first study that investigates the role of PYC in the HI brain injury model.. · PYC may be a protective agent against hypoxic-ischemic encephalopathy.. · Sevoflurane should not be preferred in rat studies where neuronal apoptosis will be investigated.. Competing Interests: None declared. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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