Clinical outcomes in COVID-19 patients infected with different SARS-CoV-2 variants in Marseille, France.

Autor:	Dao TL; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet nam., Hoang VT; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet nam., Nguyen NN; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France., Delerce J; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France., Chaudet H; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France., Levasseur A; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France., Lagier JC; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France., Raoult D; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France., Colson P; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France., Gautret P; Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; Institut Hospitalo-Universitaire-Méditerranée Infection, Marseille, France. Electronic address: philippe.gautret@club-internet.fr.
Jazyk:	angličtina
Zdroj:	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2021 Oct; Vol. 27 (10), pp. 1516.e1-1516.e6. Date of Electronic Publication: 2021 May 24.
DOI:	10.1016/j.cmi.2021.05.029
Abstrakt:	Objectives: To compare the clinical and epidemiological aspects associated with different predominant lineages circulating in Marseille from March 2020 to January 2021. Methods: In this single-centre retrospective cohort study, characteristics of patients infected with four different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants were documented from medical files. The outcome was the occurrence of clinical failure, defined as hospitalization (for outpatients), transfer to the intensive care unit (inpatients) and death (all). Results: A total of 254 patients were infected with clade 20A (20AS), 85 with Marseille-1 (M1V), 190 with Marseille-4 (M4V) and 211 with N501Y (N501YV) variants. 20AS presented a bell-shaped epidemiological curve and nearly disappeared around May 2020. M1V reached a very weak peak, then disappeared after six weeks. M4V appeared in July presented an atypical wave form for 7 months. N501YV has only recently appeared. Compared with 20AS, patients infected with M1V were less likely to report dyspnoea (adjusted odds ratio (OR) 0.50, p 0.04), rhinitis (aOR 0.57, p 0.04) and to be hospitalized (aOR 0.22, p 0.002). Patients infected with M4V were more likely to report fever than those with 20AS and M1V (aOR 2.49, p < 0.0001 and aOR 2.30, p 0.007, respectively) and to be hospitalized than those with M1V (aOR 4.81, p 0.003). Patients infected with N501YV reported lower rate of rhinitis (aOR 0.50, p 0.001) and anosmia (aOR 0.57, p 0.02), compared with those infected with 20AS. A lower rate of hospitalization was associated with N501YV infection compared with 20AS and M4V (aOR 0.33, p < 0.0001 and aOR 0.27, p < 0.0001, respectively). Conclusions: The four lineages have presentations that differ from one another, epidemiologically and clinically. This supports SARS-CoV-2 genomic surveillance through next-generation sequencing. (Copyright © 2021 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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