Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.

Autor: Chisenga CC; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Bosomprah S; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.; Department of Biostatistics, School of Public Health, University of Ghana, Accra, Ghana., Simuyandi M; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Mwila-Kazimbaya K; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Chilyabanyama ON; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Laban NM; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Bialik A; School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Asato V; School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Meron-Sudai S; School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Frankel G; Imperial College London, London, United Kingdom., Cohen D; School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Chilengi R; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 May 27; Vol. 16 (5), pp. e0252222. Date of Electronic Publication: 2021 May 27 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0252222
Abstrakt: Introduction: Shigellosis, is a leading cause of moderate-to-severe diarrhoea and related mortality in young children in low and middle income countries (LMICs). Knowledge on naturally acquired immunity can support the development of Shigella candidate vaccines mostly needed in LMICs. We aimed to quantify Shigella-specific antibodies of maternal origin and those naturally acquired in Zambian infants.
Methods: Plasma samples collected from infants at age 6, 14 and 52-weeks were tested for Shigella (S. sonnei and S. flexneri 2a) lipopolysaccharide (LPS) antigen specific immunoglobulin G (IgG) and A (IgA) by enzyme-linked immunosorbent assay.
Results: At 6 weeks infant age, the IgG geometric mean titres (GMT) against S. sonnei (N = 159) and S. flexneri 2a (N = 135) LPS were 311 (95% CI 259-372) and 446 (95% CI 343-580) respectively. By 14 weeks, a decline in IgG GMT was observed for both S. sonnei to 104 (95% CI 88-124), and S. flexneri 2a to 183 (95% CI 147-230). Both S. sonnei and S. flexneri 2a specific IgG GMT continued to decrease by 52 weeks infant age when compared to 6 weeks. In 27% and 8% of infants a significant rise in titre (4 fold and greater) against S. flexneri 2a and S. sonnei LPS, respectively, was detected between the ages of 14 and 52 weeks. IgA levels against both species LPS were very low at 6 and 14 weeks and raised significantly against S. flexneri 2a and S. sonnei LPS in 29% and 10% of the infants, respectively.
Conclusion: In our setting, transplacental IgG anti-Shigella LPS is present at high levels in early infancy, and begins to decrease by age 14 weeks. Our results are consistent with early exposure to Shigella and indicate naturally acquired IgG and IgA antibodies to S. flexneri 2a and S. sonnei LPS in part of infants between 14 and 52 weeks of age. These results suggest that a potential timing of vaccination would be after 14 and before 52 weeks of age to ensure early infant protection against shigellosis.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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