Pagetoid involvement of bronchioles by metastatic breast carcinoma.

Autor:	Guerrieri C; Department of Pathology, Immunology and Molecular Pathology, Rutgers New Jersey Medical School, Newark, NJ., Sesti J; Department of Thoracic Surgery, RWJ Barnabas Health, West Orange, NJ., Gupta S; Department of Pathology, Immunology and Molecular Pathology, Rutgers New Jersey Medical School, Newark, NJ., Hudacko R; Department of Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Jazyk:	angličtina
Zdroj:	Pathologica [Pathologica] 2021 Apr; Vol. 113 (2), pp. 121-125.
DOI:	10.32074/1591-951X-128
Abstrakt:	We report a case of a 36-year-old female with endobronchiolar spread of breast carcinoma in the lung. The patient had recently been diagnosed with invasive ductal breast carcinoma and imaging of the lungs revealed bilateral lung nodules. She then underwent a wedge resection of a lung nodule. The biopsy revealed a subpleural metastatic nodule of invasive ductal carcinoma with an intra-alveolar pattern of spread at its advancing edge. Several smaller foci of intra-alveolar tumor were noted as well as pagetoid spread of tumor cells along a 0.9 mm wide bronchiole. The neoplastic cells were TTF-1 negative, GATA3 positive and ER positive. This is the third reported case of pagetoid spread of metastatic breast carcinoma along the bronchial tree. This case emphasizes the importance of examining not only bronchi but also bronchioles to detect this unusual pattern of spread of metastatic breast carcinoma in lung resection specimens. (Copyright © 2021 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.)
Databáze:	MEDLINE
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