Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery.

Autor: Conradi N; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany. Nadine.Conradi@kgu.de.; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany. Nadine.Conradi@kgu.de., Rosenberg F; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany., Knake S; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany.; Department of Neurology, Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Biermann L; Department of Neurology, Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Haag A; Department of Neurology, Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Gorny I; Department of Neurology, Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Hermsen A; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany., von Podewils V; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Behrens M; Department of Neurology, University Hospital Frankfurt and Goethe University, Frankfurt am Main, Germany., Gurschi M; Department of Neuroradiology, Philipps-University Marburg, Marburg, Germany., du Mesnil de Rochemont R; Institute of Neuroradiology, University Hospital Frankfurt and Goethe University, Frankfurt am Main, Germany., Menzler K; Department of Neurology, Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany., Bauer S; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany., Schubert-Bast S; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany.; Department of Neuropediatrics, University Hospital Frankfurt and Goethe University, Frankfurt am Main, Germany., Nimsky C; Department of Neurosurgery, Philipps-University Marburg, Marburg, Germany., Konczalla J; Department of Neurosurgery, University Hospital Frankfurt and Goethe University, Frankfurt am Main, Germany., Rosenow F; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany., Strzelczyk A; Department of Neurology, Epilepsy Center Frankfurt Rhine-Main, University Hospital Frankfurt and Goethe University, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.; LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University, Frankfurt am Main, Germany.; Department of Neurology, Epilepsy Center Hessen, Philipps-University Marburg, Marburg, Germany.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 May 26; Vol. 11 (1), pp. 10979. Date of Electronic Publication: 2021 May 26.
DOI: 10.1038/s41598-021-90376-3
Abstrakt: In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients' verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R 2  = 0.233, p = .032) and verbal memory function (∆R 2  = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.
Databáze: MEDLINE
Externí odkaz: