Reduced adaptation of glutamatergic stress response is associated with pessimistic expectations in depression.

Autor: Cooper JA; Department of Psychology, Emory University, Atlanta, GA, USA. j.cooper@emory.edu., Nuutinen MR; Department of Psychology, Emory University, Atlanta, GA, USA., Lawlor VM; Department of Psychology, Emory University, Atlanta, GA, USA., DeVries BAM; Department of Psychology, Emory University, Atlanta, GA, USA., Barrick EM; Center for Depression, Anxiety and Stress Research, McLean Hospital/Harvard Medical School, Belmont, MA, USA., Hossein S; Department of Psychology, Emory University, Atlanta, GA, USA., Cole DJ; Department of Psychology, Emory University, Atlanta, GA, USA., Leonard CV; Department of Psychology, Emory University, Atlanta, GA, USA., Hahn EC; Department of Psychology, Emory University, Atlanta, GA, USA., Teer AP; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA., Shields GS; Department of Psychological Science, University of Arkansas, Fayetteville, AR, USA., Slavich GM; Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA., Ongur D; Department of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA, USA., Jensen JE; McLean Imaging Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA., Du F; McLean Imaging Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA., Pizzagalli DA; Center for Depression, Anxiety and Stress Research, McLean Hospital/Harvard Medical School, Belmont, MA, USA.; Department of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA, USA.; McLean Imaging Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA., Treadway MT; Department of Psychology, Emory University, Atlanta, GA, USA. mtreadway@emory.edu.; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA. mtreadway@emory.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 May 26; Vol. 12 (1), pp. 3166. Date of Electronic Publication: 2021 May 26.
DOI: 10.1038/s41467-021-23284-9
Abstrakt: Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy control samples and a third sample of unmedicated participants with MDD who completed the Maastricht acute stress task, and one sample of healthy control participants who completed a no-stress control manipulation. In healthy controls, we find that the magnitude of mPFC glutamate response to the acute stressor decreases as individual levels of perceived stress increase. This adaptative glutamate response is absent in individuals with MDD and is associated with pessimistic expectations during a 1-month follow-up period. Together, this work shows evidence for glutamatergic adaptation to stress that is significantly disrupted in MDD.
Databáze: MEDLINE
Externí odkaz: