Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis.

Autor:	Chen ZJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Lu SY; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Rong SS; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA., Ho M; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China., Ng DS; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Chen H; Joint Shantou International Eye Center, Shantou University, Shantou, China., Gong B; Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China., Yam JC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Young AL; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China., Brelen M; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China., Tham CC; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Joint Shantou International Eye Center, Shantou University, Shantou, China., Chen LJ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China lijia_chen@cuhk.edu.hk.; Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2022 Nov; Vol. 106 (11), pp. 1542-1548. Date of Electronic Publication: 2021 May 26.
DOI:	10.1136/bjophthalmol-2021-318953
Abstrakt:	Aims: To identify single-nucleotide polymorphisms (SNPs) associated with central serous chorioretinopathy (CSCR) by a systematic review and meta-analysis, and to compare the association profiles between CSCR, neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). Methods: We searched the EMBASE, PubMed and Web of Science for genetic studies of CSCR from the starting dates of the databases to 12 September 2020. We then performed meta-analyses on all SNPs reported by more than two studies and calculated the pooled OR and 95% CIs. We also conducted sensitivity analysis and adopted the funnel plot to assess potential publication bias. Results: Totally 415 publications were reviewed, among them 10 were eligible for meta-analysis. We found 10 SNPs that have been reported at least twice. Meta-analysis and sensitivity analysis confirmed significant associations between CSCR and six SNPs in three genes, namely age-related maculopathy susceptibility 2 ( ARMS2 ) (rs10490924, OR=1.37; p=0.00064), complement factor H ( CFH ) (rs800292, OR=1.44; p=7.80×10 -5 ; rs1061170, OR=1.34; p=0.0028; rs1329428, OR=1.40; p=0.012; and rs2284664, OR=1.36; p=0.0089) and tumour necrosis factor receptor superfamily, member 10a ( TNFRSF10A ) (rs13278062, OR=1.34; p=1.44×10 -15 ). Among them, only TNFRSF10A rs13278062 showed the same trend of effect on CSCR, nAMD and PCV, while the SNPs in ARMS2 and CFH showed opposite trends in the SNP associations. Conclusions: This study confirmed the associations of ARMS2 , CFH and TNFRSF10A with CSCR, and revealed that ARMS2 , CFH and TNFRSF10A may affect different phenotypic expressions of CSCR, nAMD and PCV. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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