Effect of pre-operative internal obturator muscle mass index in MRI on biochemical recurrence of prostate cancer patients after radical prostatectomy: a multi-center study.

Autor: Kim WT; Department of Urology, College of Medicine, Chungbuk National University, 62, Kaeshin-dong, Heungduk-ku, Cheongju, Chungbuk, 361-711, South Korea.; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea., Kang HW; Department of Urology, College of Medicine, Chungbuk National University, 62, Kaeshin-dong, Heungduk-ku, Cheongju, Chungbuk, 361-711, South Korea.; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea., Seo SP; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea., Kim YJ; Department of Urology, College of Medicine, Chungbuk National University, 62, Kaeshin-dong, Heungduk-ku, Cheongju, Chungbuk, 361-711, South Korea.; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea., Lee SC; Department of Urology, College of Medicine, Chungbuk National University, 62, Kaeshin-dong, Heungduk-ku, Cheongju, Chungbuk, 361-711, South Korea.; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea., Kim WJ; Department of Urology, College of Medicine, Chungbuk National University, 62, Kaeshin-dong, Heungduk-ku, Cheongju, Chungbuk, 361-711, South Korea.; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea., Cho BS; Department of Radiology, College of Medicine, Chungbuk National University, Cheongju, South Korea., Ha YS; Department of Urology, College of Medicine, Kyungpook National University, Daegu, South Korea., Kwon TG; Department of Urology, College of Medicine, Kyungpook National University, Daegu, South Korea., Park J; Department of Urology, College of Medicine, Eulji University, Daejeon, South Korea., Park SC; Department of Urology, College of Medicine, Won Kang University, Iksan, South Korea., Jeong YB; Department of Urology, College of Medicine, Jeonbuk National University, Jeonju, South Korea., Kang TW; Department of Urology, College of Medicine, Jeonnam National University, Kwangju, South Korea., Park SW; Department of Urology, College of Medicine, Pusan National University, Pusan, South Korea., Yun SJ; Department of Urology, College of Medicine, Chungbuk National University, 62, Kaeshin-dong, Heungduk-ku, Cheongju, Chungbuk, 361-711, South Korea. sjyun@chungbuk.ac.kr.; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea. sjyun@chungbuk.ac.kr.
Jazyk: angličtina
Zdroj: BMC urology [BMC Urol] 2021 May 26; Vol. 21 (1), pp. 85. Date of Electronic Publication: 2021 May 26.
DOI: 10.1186/s12894-021-00853-0
Abstrakt: Background: Recent reports show that the pre-operative or post-operative skeletal mass index (sarcopenia) affects survival rates for various cancers; however, the link between prostate cancer survival and sarcopenia is unclear. Therefore, this study examined the effect of the pre-operative internal obturator muscle (IOM) mass index on biochemical recurrence (BCR) of prostate cancer (PCa) patients who underwent radical prostatectomy.
Methods: In total, 222 patients, who underwent open, laparoscopic, or robot-assisted radical prostatectomy at seven centers in 2011 and were followed up for 5 years, were enrolled. BCR was examined in the context of pre-operative IOM mass index and BMI.
Results: The mean age of the patients was 67.82 ± 6.23 years, and the mean pre-operative prostate-specific antigen (PSA) level was 11.61 ± 13.22 ng/ml. There was no significant difference in baseline characteristics between the low and high IOM mass index groups (p > 0.05). Age, pre-op PSA level, ECE, and T-stage were associated with BCR (p = 0.049, p < 0.001, p = 0.001, p = 0.004, respectively). BMI, prostate volume, Gleason score, resection margin, N-stage, M-stage and IOM mass index was not associated with BCR (p > 0.05).
Conclusions: Pre-operative IOM mass index was not associated with BCR; however, long-term follow-up is necessary to evaluate cancer-specific and overall survival of PCa patients.
Databáze: MEDLINE
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