Hypericin in photobiological assays: An overview.

Autor: de Andrade GP; Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC, Av. dos Estados, 5001, Bairro Bangú, Santo André, SP, Brasil., de Souza TFM; Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC, Av. dos Estados, 5001, Bairro Bangú, Santo André, SP, Brasil., Cerchiaro G; Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC, Av. dos Estados, 5001, Bairro Bangú, Santo André, SP, Brasil., Pinhal MADS; Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, Vila Clementino, São Paulo, SP, Brasil., Ribeiro AO; Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC, Av. dos Estados, 5001, Bairro Bangú, Santo André, SP, Brasil. Electronic address: anderson.ribeiro@ufabc.edu.br., Girão MJBC; Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100, Vila Clementino, São Paulo, SP, Brasil.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2021 Sep; Vol. 35, pp. 102343. Date of Electronic Publication: 2021 May 24.
DOI: 10.1016/j.pdpdt.2021.102343
Abstrakt: Hypericin is considered a potent photosensitizer for use in antitumor and antimicrobial photodynamic therapy (PDT). This review presents the primary biological results obtained with hypericin in photodynamic therapy applications, such as photodynamic cancer treatment, photoinactivation of microorganisms (PDI), tissue scarring, and photo diagnosis. We present a compilation of in vitro results that have been published thus far; for these studies, we highlight the hypericin concentration, light dose, and other experimental conditions to evaluate the efficiency of photodynamic treatment like cell death, cell viability, or cell proliferation. The results indicate that different hypericin phototoxicity levels can be observed according to the specific light dose and concentration. Furthermore, it was shown that cellular localization and cell death mechanisms (apoptosis and necrosis) are dependent on the cell type.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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