Task-dependent mixed selectivity in the subiculum.

Autor:	Ledergerber D; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway. Electronic address: debora.lederberber@kliniklengg.ch., Battistin C; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway., Blackstad JS; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway., Gardner RJ; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway., Witter MP; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway., Moser MB; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway., Roudi Y; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway. Electronic address: yasser.roudi@ntnu.no., Moser EI; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway. Electronic address: edvard.moser@ntnu.no.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2021 May 25; Vol. 35 (8), pp. 109175.
DOI:	10.1016/j.celrep.2021.109175
Abstrakt:	CA1 and subiculum (SUB) connect the hippocampus to numerous output regions. Cells in both areas have place-specific firing fields, although they are more dispersed in SUB. Weak responses to head direction and running speed have been reported in both regions. However, how such information is encoded in CA1 and SUB and the resulting impact on downstream targets are poorly understood. Here, we estimate the tuning of simultaneously recorded CA1 and SUB cells to position, head direction, and speed. Individual neurons respond conjunctively to these covariates in both regions, but the degree of mixed representation is stronger in SUB, and more so during goal-directed spatial navigation than free foraging. Each navigational variable could be decoded with higher precision, from a similar number of neurons, in SUB than CA1. The findings point to a possible contribution of mixed-selective coding in SUB to efficient transmission of hippocampal representations to widespread brain regions. Competing Interests: Declarations of interests The authors declare no competing interests. (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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