Obstructive Sleep Apnea and Pulmonary Hypertension: A Review of Literature.
| Autor: | Shah FA; Internal Medicine, Lewis Gale Medical Center, Salem, USA., Moronta S; Internal Medicine, Edward Via College of Osteopathic Medicine, Salem, USA., Braford M; Internal Medicine, Edward Via College of Osteopathic Medicine, Salem, USA., Greene N; Pulmonary and Critical Care, Lewis Gale Medical Center, Salem, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Apr 20; Vol. 13 (4), pp. e14575. Date of Electronic Publication: 2021 Apr 20. |
| DOI: | 10.7759/cureus.14575 |
| Abstrakt: | Obstructive sleep apnea (OSA) is a disease process involving recurrent pharyngeal collapse during sleep, resulting in apneic episodes. Clinically, symptoms can include snoring, sudden awakening with a choking-like sensation, excessive somnolence, non-restorative sleep, difficulty in starting or maintaining sleep, and fatigue. It results in impaired gas exchange, subsequently causing various cardiovascular, metabolic, and neurocognitive pathologies. Historically, OSA has been underdiagnosed and undertreated, especially in women. OSA is associated with WHO (World Health Organization) class III pulmonary hypertension (PH) or PH due to lung disease. PH is a concerning complication of OSA and thought to occur in roughly 20% of individuals with OSA. The pathogenesis of PH in OSA can include pulmonary artery vasoconstriction and remodeling. Patients suffering from OSA who develop PH tend to have worse cardiovascular and pulmonary changes. We present a thorough review of the literature examining the interplay between OSA and PH. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Shah et al.) |
| Databáze: | MEDLINE |
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