An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering.

Autor: Ritzau-Reid KI; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK., Spicer CD; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Chemistry, York Biomedical Research Institute, University of York, Heslington YO10 5DD, UK., Gelmi A; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK; Applied Chemistry and Environmental Science, School of Science, RMIT University, Melbourne 3000, Australia., Grigsby CL; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden., Ponder JF Jr; Department of Chemistry, Imperial College London, London SW7 2AZ, UK., Bemmer V; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK., Creamer A; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK., Vilar R; Department of Chemistry, Imperial College London, London SW7 2AZ, UK., Serio A; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK; Centre for Craniofacial & Regenerative Biology, King's College London and The Francis Crick Institute, Tissue Engineering and Biophotonics Division, Dental Institute, King's College London, London SE1 9RT, UK., Stevens MM; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London SW7 2AZ, UK; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden.
Jazyk: angličtina
Zdroj: Advanced functional materials [Adv Funct Mater] 2020 Aug 14; Vol. 30 (42), pp. 2003710. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).
DOI: 10.1002/adfm.202003710
Abstrakt: The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.
Competing Interests: Conflict of Interest The authors declare no conflict of interest.
Databáze: MEDLINE
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