Multiple parietal pathways are associated with rTMS-induced hippocampal network enhancement and episodic memory changes.

Autor: Freedberg M; Behavioral Neurology Unit, NINDS, 9000 Rockville Pike, 10 Center Drive, Rm. 7-5659, Bethesda 20892, MD, USA. Electronic address: michael.freedberg@nih.gov., Cunningham CA; Behavioral Neurology Unit, NINDS, 9000 Rockville Pike, 10 Center Drive, Rm. 7-5659, Bethesda 20892, MD, USA., Fioriti CM; Behavioral Neurology Unit, NINDS, 9000 Rockville Pike, 10 Center Drive, Rm. 7-5659, Bethesda 20892, MD, USA. Electronic address: cynthia.fioriti@nih.gov., Murillo J; Behavioral Neurology Unit, NINDS, 9000 Rockville Pike, 10 Center Drive, Rm. 7-5659, Bethesda 20892, MD, USA. Electronic address: jorgedorado.murillo@nih.gov., Reeves JA; Behavioral Neurology Unit, NINDS, 9000 Rockville Pike, 10 Center Drive, Rm. 7-5659, Bethesda 20892, MD, USA. Electronic address: jackreev@buffalo.edu., Taylor PA; Scientific and Statistical Computing Core, NIMH, NIH, Bethesda, MD, USA. Electronic address: paul.taylor@nih.gov., Sarlls JE; NIH MRI Research Facility, NINDS, NIH, Bethesda, MD, USA. Electronic address: sarllsjo@mail.nih.gov., Wassermann EM; Behavioral Neurology Unit, NINDS, 9000 Rockville Pike, 10 Center Drive, Rm. 7-5659, Bethesda 20892, MD, USA. Electronic address: wassermanne@nih.gov.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2021 Aug 15; Vol. 237, pp. 118199. Date of Electronic Publication: 2021 May 24.
DOI: 10.1016/j.neuroimage.2021.118199
Abstrakt: Repetitive transcranial magnetic stimulation (rTMS) of the inferior parietal cortex (IPC) increases resting-state functional connectivity (rsFC) of the hippocampus with the precuneus and other posterior cortical areas and causes proportional improvement of episodic memory. The anatomical pathway(s) responsible for the propagation of these effects from the IPC is unknown and may not be direct. In order to assess the relative contributions of candidate pathways from the IPC to the MTL via the parahippocampal cortex and precuneus, to the effects of rTMS on rsFC and memory improvement, we used diffusion tensor imaging to measure the extent to which individual differences in fractional anisotropy (FA) in these pathways accounted for individual differences in response. FA in the IPC-parahippocampal pathway and several MTL pathways predicted changes in rsFC. FA in both parahippocampal and hippocampal pathways was related to changes in episodic, but not procedural, memory. These results implicate pathways to the MTL in the enhancing effect of parietal rTMS on hippocampal rsFC and memory.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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