SARS-CoV-2 RNA may rarely be present in a uterine cervix LBC sample at the asymptomatic early stage of COVID 19 disease.

Autor: Ondič O; Department of Pathology, Medical Faculty, Charles University and Charles University Hospital Pilsen, Pilsen, Czech Republic.; Bioptická Laboratoř, s.r.o., Pilsen, Czech Republic., Černá K; Department of Pathology, Medical Faculty, Charles University and Charles University Hospital Pilsen, Pilsen, Czech Republic.; Bioptická Laboratoř, s.r.o., Pilsen, Czech Republic., Kinkorová-Luňáčková I; Bioptická Laboratoř, s.r.o., Pilsen, Czech Republic., Němcová J; Department of Pathology, Medical Faculty, Charles University and Charles University Hospital Pilsen, Pilsen, Czech Republic.; Bioptická Laboratoř, s.r.o., Pilsen, Czech Republic., Mejchar B; Private Gynaecologist Office, Pilsen, Czech Republic., Chytra J; Department of Gynecology and Obstetrics, Medical Faculty, Charles University and Charles University Hospital Pilsen, Pilsen, Czech Republic., Bouda J; Department of Gynecology and Obstetrics, Medical Faculty, Charles University and Charles University Hospital Pilsen, Pilsen, Czech Republic.
Jazyk: angličtina
Zdroj: Cytopathology : official journal of the British Society for Clinical Cytology [Cytopathology] 2021 Nov; Vol. 32 (6), pp. 766-770. Date of Electronic Publication: 2021 May 31.
DOI: 10.1111/cyt.12995
Abstrakt: Objective: Currently, it is thought that uterine cervix mucosal samples present a low risk of SARS-CoV-2 exposure. So far, there is no evidence of SARS-CoV-2 detection in Papanicolaou (Pap) smears. Nevertheless, clinicians could be exposed unaware to the coronavirus while performing and handling a Pap smear. We aimed to retrospectively evaluate the presence of SARS-CoV-2 RNA in cervical liquid-based cytology (LBC) samples in women who tested positive for a nasopharyngeal COVID-19 PCR test.
Methods: From our laboratory database, we identified patients with data on a cervical cancer screening LBC sample paired with a positive nasopharyngeal COVID-19 PCR test. Relevant LBC samples taken within an incubation period of 14 days and post-onset RNA shedding interval of 25 days were subsequently tested for SARS-CoV-2 RNA using RT-PCR tests.
Results: The study group consisted of 102 women. Of those, 23 LBC samples were tested. SARS-CoV-2 RNA was detected in one LBC sample from a 26-year-old asymptomatic woman taken six days before reporting headaches and knee arthralgia with a positive nasopharyngeal SARS-CoV-2 RT-PCR test.
Conclusions: It is possible to detect SARS-CoV-2 RNA in cervical LBC samples at an early asymptomatic stage of COVID-19. In general, this finding is infrequent in asymptomatic women who tested SARS-CoV-2 positive within an incubation of 14 days and a post-onset RNA shedding period of 25 days. We fully support the current thinking that cervical LBC samples from asymptomatic women pose a low risk of SARS-CoV-2 exposure and can be handled in the frame of good microbiological practice and procedures.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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