Molecular diagnosis in cat allergy.
| Autor: | Popescu FD; Department of Allergology and Clinical Immunology, 'Nicolae Malaxa' Clinical Hospital, Bucharest 022441, Romania., Ganea CS; Department of Allergology and Clinical Immunology, 'Nicolae Malaxa' Clinical Hospital, Bucharest 022441, Romania., Panaitescu C; Department III Functional Sciences, Physiology Discipline, 'Victor Babes' University of Medicine and Pharmacy, Timișoara 300041, Romania., Vieru M; Department of Allergology and Clinical Immunology, 'Nicolae Malaxa' Clinical Hospital, Bucharest 022441, Romania. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of methodology [World J Methodol] 2021 May 20; Vol. 11 (3), pp. 46-60. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021). |
| DOI: | 10.5662/wjm.v11.i3.46 |
| Abstrakt: | Domestic cats represent one of the most common sources of indoor allergens. All over the world, many households own cats, whose allergens are persistent and widespread. Cat allergy itself is frequent, and its symptoms vary from rhinoconjunctivitis to life-threatening asthma. In vitro diagnosis using precision medicine allergy immunoassays is important because natural cat dander extracts may differ in quality and quantity of some of the individual allergen components and other molecules. In the component-resolved diagnosis of cat allergy, singleplex and multiplex specific immunoglobulin (Ig) E assays include use of the cat-specific major allergen, secretoglobin Fel d 1 (as a species-specific molecule), other allergen components (such as lipocalins Fel d 4, cross-reacting with other animal similar molecules, and Fel d 7, present in small quantities in natural extracts), and serum albumin Fel d 2 (related to the cat-pork syndrome). IgA Fel d 5 and IgM Fel d 6 are not available as allergen components in the current commercial IgE immunoassays, but they may impair the in vitro diagnostic evaluation of cat allergy because galactose-α1,3-galactose is an IgE-binding epitope of these native feline allergens. The benefits of molecular-based cat allergy diagnosis are continually evaluated, as the role of recombinant allergen components already known is detailed and new other molecules of interest may be discovered in the future. Competing Interests: Conflict-of-interest statement: The authors declare no conflicts of interest. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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