SARS-CoV-2 RT-PCR positivity and antibody prevalence among asymptomatic hospital-based health care workers.

Autor: Johnson CC; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, United States. Electronic address: cjohnson1@hfhs.org., Coleman CM; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, United States., Sitarik AR; Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, United States., Leon JE; Population Health, Henry Ford Health System, Detroit, MI, United States., Tibbetts RJ; Department of Pathology, Henry Ford Health System, Detroit, MI, United States., Cook BC; Department of Pathology, Henry Ford Health System, Detroit, MI, United States., Muma BK; Population Health, Henry Ford Health System, Detroit, MI, United States., Weinmann AJ; Division of Infectious Diseases, Department of Medicine, Henry Ford Health System, Detroit, MI, United States., Samuel LP; Department of Pathology, Henry Ford Health System, Detroit, MI, United States.
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2021 Jul; Vol. 140, pp. 104794. Date of Electronic Publication: 2021 Mar 16.
DOI: 10.1016/j.jcv.2021.104794
Abstrakt: Background: The level of asymptomatic infection with SARS-CoV-2 could be substantial and among health care workers (HCWs) a source of continuing transmission of the virus to patients and co-workers.
Objectives: Measure the period prevalence of SARS-CoV-2 PCR positivity and seroprevalence of SARS-CoV-2 IgG antibodies among a random sample of asymptomatic health system hospital-based health care workers (HCWs) 6½ -15½ weeks after 4/5/2020, the peak of the first surge of COVID-19 admissions.
Results: Of 524 eligible and consented participants from four metropolitan hospitals, nasopharyngeal swabs were obtained from 439 (83.8 %) and blood from 374 (71.4 %). Using PCR nucleic acid-based amplification (NAAT) methods, the period prevalence of SARS-CoV-2 infection was 0.23 % (95 % confidence interval (CI) 0.01 %-1.28 %; 1/439) from 5/21/20-7/16/20. The seroprevalence of SARS-CoV-2 IgG antibodies from June 17-July 24, 2020 was 2.41 % (95 % CI 1.27 %-4.51 %; 9/374). Those who were reactive were younger (median age 36 versus 44 years; p = 0.050), and those with self-reported Hispanic/Latino ethnicity had a higher seroprevalence (2/12 = 16.7 % versus 7/352 = 2.0 %; p = 0.051). There were no significant differences by sex, race, residence, hospital, unit or job type. The one employee who was found to be PCR test positive in this study was also reactive for IgG antibodies, tested 27 days later.
Conclusions: The period prevalence of PCR positivity to SARS-CoV-2 and IgG seroprevalence was unexpectedly low in asymptomatic HCWs after a peak in COVID-19 admissions and the establishment of state and institutional infection control policies, suggesting that routine screening tests while community prevalence is relatively low would produce a minimal yield.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: