The baboon in epilepsy research: Revelations and challenges.

Autor: Szabó CÁ; Departments of Neurology, UT Health San Antonio, San Antonio, TX, United States. Electronic address: szabo@uthscsa.edu., Salinas FS; Radiology, UT Health San Antonio, San Antonio, TX, United States; Research Imaging Institute, UT Health San Antonio, San Antonio, TX, United States.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2021 Aug; Vol. 121 (Pt A), pp. 108012. Date of Electronic Publication: 2021 May 19.
DOI: 10.1016/j.yebeh.2021.108012
Abstrakt: The baboon offers a natural model for genetic generalized epilepsy with photosensitivity. In this review, we will summarize some of the more important clinical, neuroimaging, and elctrophysiological findings form recent work performed at the Southwest National Primate Research Center (SNPRC, Texas Biomedical Research Institute, San Antonio, Texas), which houses the world's largest captive baboon pedigree. Due to the phylogenetic proximity of the baboon to humans, many of the findings are readily translatable, but there may be some important differences, such as the mutlifocality of the ictal and interictal epileptic discharges (IEDs) on intracranial electroencephalography (EEG) and greater parieto-occipital connectivity of baboon brain networks compared to juvenile myoclonic epilepsy in humans. Furthermore, there is still limited knowledge of the natural history of the epilepsy, which could be transformative for research into epileptogenesis in genetic generalized epilepsy (GGE) and sudden unexpected death in epilepsy (SUDEP).
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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