Polysaccharides and extracts from Agaricus brasiliensis Murill - A comprehensive review.

Autor:	da Silva Campelo M; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil., Neto JFC; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil., Lima ABN; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil., das Chagas Neto FC; Centro de Estudos Farmacêuticos e Cosméticos, Departamento de Farmácia, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60430-160, Brasil., da Costa Gonzaga ML; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil., de Aguiar Soares S; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil., Leal LKAM; Centro de Estudos Farmacêuticos e Cosméticos, Departamento de Farmácia, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60430-160, Brasil. Electronic address: kalyne@ufc.br., Ribeiro MENP; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil. Electronic address: elenir.ribeiro@ufc.br., Ricardo NMPS; Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza - CE, CEP: 60455-760, Brasil. Electronic address: naricard@ufc.br.
Jazyk:	angličtina
Zdroj:	International journal of biological macromolecules [Int J Biol Macromol] 2021 Jul 31; Vol. 183, pp. 1697-1714. Date of Electronic Publication: 2021 May 19.
DOI:	10.1016/j.ijbiomac.2021.05.112
Abstrakt:	Edible mushrooms have been increasingly introduced into the human diet, which has driven research into their functional properties. Thus, Agaricus brasiliensis Murill or Agaricus blazei Murill (ABM) is a species native to the Brazilian biome, whose fruiting body has been used not only for dietary purposes, but also in the development of functional foods or as source of molecules of pharmacological interest. The bioactivity of ABM has been related to the presence of polysaccharides, although the contribution of other metabolites cannot be discharged. This work describes the polysaccharides isolation methodology and preparation of the extracts of ABM and their biological activities. Furthermore, it presents a general outline of its characterizations regarding composition, chemical structure and properties in solution. The ABM and its chemical constituents exhibit several biological activities that support their potential use for prevention or treatment of diseases with inflammatory background, such as cancer, diabetes and atherosclerosis. The mechanism of action of the extracts and polysaccharides from ABM is mainly related to a modulation of immune system response or reduction of inflammatory response. This review shows that the ABM has great potential in the pharmaceutical, biotechnological and food sectors that deserves additional research using standardized products. (Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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