Toxicological Impacts on Antioxidant Responses, Stress Protein, and Genotoxicity Parameters of Aluminum Oxide Nanoparticles in the Liver of Oreochromis niloticus.

Autor: Temiz Ö; Vocational School of Health Services, Osmaniye Korkut Ata University, 80000, Osmaniye, Turkey. temizozge@gmail.com., Kargın F; Department of Biology, Faculty of Science and Letters, Çukurova University, 01330, Adana, Turkey.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2022 Mar; Vol. 200 (3), pp. 1339-1346. Date of Electronic Publication: 2021 May 21.
DOI: 10.1007/s12011-021-02723-0
Abstrakt: The aim of this study was to determine the toxic effects of aluminum oxide nanoparticles (Al 2 O 3 NPs) on oxidative stress, stress protein, and genotoxicity parameters in Oreochromis niloticus. Ninety-six-hour LC 50 value of Al 2 O 3 NPs was found as 52.4 ppm for O. niloticus. The fish were exposed to 2.6 ppm (5% of the 96-h LC 50 ) and 5.2 ppm (10% of the 96-h LC 50 ) for 3 days and 7 days. Various biochemical parameters, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) activities, glutathione (GSH), thiobarbituric acid reactive substance (TBARS), heat shock protein 70 (HSP70; stress protein), and genotoxicity biomarker 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, were determined. Results showed that antioxidant enzymes were significantly decreased in SOD, CAT, and GPx enzyme activity, but GST enzyme activity was significantly increased in 7 days. The oxidative stress parameters, GSH levels, were significantly decreased while 8-OHdG and TBARS levels were increased in 3 and 7 days. HSP70 levels were decreased in the concentrations of Al 2 O 3 NPs and exposure times. Our results showed that as a result of changes in oxidative stress parameters, stress protein, and genotoxicity parameters, O. niloticus liver tissue is highly sensitive and toxic to aluminum oxide nanoparticle exposure.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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