Diabetes and Prediabetes in Children With Cystic Fibrosis: A Systematic Review of the Literature and Recommendations of the Italian Society for Pediatric Endocrinology and Diabetes (ISPED).

Autor:	Mozzillo E; Department of Translational Medical Science, Section of Pediatrics, Regional Center of Pediatric Diabetes, Federico II University of Naples, Naples, Italy., Franceschi R; Pediatric Unit, S. Chiara Hospital, Trento, Italy., Piona C; Regional Center for Pediatric Diabetes, University of Verona, Verona, Italy., Passanisi S; Department of Human Pathology in Adult and Developmental Age, University of Messina, Messina, Italy., Casertano A; Department of Translational Medical Science, Section of Pediatrics, Regional Center of Pediatric Diabetes, Federico II University of Naples, Naples, Italy., Pjetraj D; SOD Pediatric Diabetology, Department of Women's and Children's, 'G. Salesi' Children's Hospital, AOU Ospedali Riuniti, Ancona, Italy., Maltoni G; Department of Woman, Child and Urological Diseases, S. Orsola-Malpighi University Hospital, Bologna, Italy., Calcaterra V; University of Pavia, Pavia and Department of Pediatrics, 'Vittore Buzzi' Children's Hospital, Milano, Italy., Cauvin V; Pediatric Unit, S. Chiara Hospital, Trento, Italy., Cherubini V; SOD Pediatric Diabetology, Department of Women's and Children's, 'G. Salesi' Children's Hospital, AOU Ospedali Riuniti, Ancona, Italy., D'Annunzio G; IRCCS Istituto Giannina Gaslini, Genova, Italy., Franzese A; Department of Translational Medical Science, Section of Pediatrics, Regional Center of Pediatric Diabetes, Federico II University of Naples, Naples, Italy., Frongia AP; Diabetes Unit, Ospedale Brotzu, Cagliari, Italy., Lombardo F; Department of Human Pathology in Adult and Developmental Age, University of Messina, Messina, Italy., Lo Presti D; Centro di Riferimento Regionale di Diabetologia Pediatrica A.O.U. Policlinico G. Rodolico, Catania, Italy., Matteoli MC; Diabetes Unit, Bambino Gesù Children's Hospital, Rome, Italy., Piccinno E; D.A.I. Pediatria, Ospedale Pediatrico Giovanni XXIII, Bari, Italy., Predieri B; Department of Medical and Surgical Sciences of the Mother, Children and Adults - Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy., Rabbone I; Division of Pediatrics, Department of Health Science, University of Piemonte Orientale, Novara, Italy., Scaramuzza AE; Diabetes & Nutrition Unit, Pediatrics, ASST Cremona, Cremona, Italy., Toni S; Pediatric Diabetology Unit, Meyer Children Hospital, Florence, Italy., Zucchini S; Department of Woman, Child and Urological Diseases, S. Orsola-Malpighi University Hospital, Bologna, Italy., Maffeis C; Regional Center for Pediatric Diabetes, University of Verona, Verona, Italy., Schiaffini R; Diabetes Unit, Bambino Gesù Children's Hospital, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Apr 29; Vol. 12, pp. 673539. Date of Electronic Publication: 2021 Apr 29 (Print Publication: 2021).
DOI:	10.3389/fendo.2021.673539
Abstrakt:	Cystic fibrosis related diabetes (CFRD) is a comorbidity of cystic fibrosis (CF) that negatively impacts on its clinical course. Prediabetes is an important predictor of either CFRD development and unfavorable prognosis of CF in both pediatric and adult patients. International guidelines recommend insulin only in case of CFRD diagnosis. Whether early detection and treatment of prediabetes may contribute to improve the clinical course of CF is still debated. A subgroup of pediatric diabetologists of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) performed a systematic review of the literature based on predefined outcomes: impact of pre-diabetes on clinical outcomes and on the risk of developing CFRD; diagnosis of diabetes and pre-diabetes under 10 years of age; effectiveness of therapy on glycemic control, impact of therapy on pulmonary function and nutritional status. Thirty-one papers were selected for the analysis data presented in these papers were reported in tables sorted by outcomes, including comprehensive evidence grading according to the GRADE approach. Following the grading of the quality of the evidence, the entire ISPED diabetes study group achieved consensus for the Italian recommendations based on both evidence and clinical experience. We concluded that in patients with CF, prediabetes should be carefully considered as it can evolve into CFRD. In patients with CF and prediabetic conditions, after complete evaluation of the OGTT trend, glucometrics, glycemic values measured during pulmonary exacerbations and/or steroid therapy, early initiation of insulin therapy could have beneficial effects on clinical outcomes of patients with CF and prediabetes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Mozzillo, Franceschi, Piona, Passanisi, Casertano, Pjetraj, Maltoni, Calcaterra, Cauvin, Cherubini, D’Annunzio, Franzese, Frongia, Lombardo, Lo Presti, Matteoli, Piccinno, Predieri, Rabbone, Scaramuzza, Toni, Zucchini, Maffeis and Schiaffini.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu