QPLOT Neurons-Converging on a Thermoregulatory Preoptic Neuronal Population.

Autor:	Upton BA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Division of Pediatric Ophthalmology, Center for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Molecular and Developmental Biology Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.; Medical Scientist Training Program, College of Medicine, University of Cincinnati, Cincinnati, OH, United States., D'Souza SP; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Division of Pediatric Ophthalmology, Center for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Molecular and Developmental Biology Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, OH, United States., Lang RA; The Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Division of Pediatric Ophthalmology, Center for Chronobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2021 May 04; Vol. 15, pp. 665762. Date of Electronic Publication: 2021 May 04 (Print Publication: 2021).
DOI:	10.3389/fnins.2021.665762
Abstrakt:	The preoptic area of the hypothalamus is a homeostatic control center. The heterogeneous neurons in this nucleus function to regulate the sleep/wake cycle, reproduction, thirst and hydration, as well as thermogenesis and other metabolic responses. Several recent studies have analyzed preoptic neuronal populations and demonstrated neuronal subtype-specific roles in suppression of thermogenesis. These studies showed similar thermogenesis responses to chemogenetic modulation, and similar synaptic tracing patterns for neurons that were responsive to cold, to inflammatory stimuli, and to violet light. A reanalysis of single-cell/nucleus RNA-sequencing datasets of the preoptic nucleus indicate that these studies have converged on a common neuronal population that when activated, are sufficient to suppress thermogenesis. Expanding on a previous name for these neurons (Q neurons, which reflect their ability to promote quiescence and expression of Qrfp ), we propose a new name: QPLOT neurons, to reflect numerous molecular markers of this population and to capture its broader roles in metabolic regulation. Here, we summarize previous findings on this population and present a unified description of QPLOT neurons, the excitatory preoptic neuronal population that integrate a variety of thermal, metabolic, hormonal and environmental stimuli in order to regulate metabolism and thermogenesis. Competing Interests: The Lang lab has a sponsored research agreement with BIOS Lighting Inc. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Upton, D’Souza and Lang.)
Databáze:	MEDLINE
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