Thermoresponsive Pluronic based microgels for controlled release of curcumin against breast cancer cell line.

Autor: Kulkarni AS; Department of Chemistry, Savitribai Phule Pune University, (Formerly, University of Pune), Pune, 411007, India., Tapase SR; Department of Chemistry, Savitribai Phule Pune University, (Formerly, University of Pune), Pune, 411007, India., Kodam KM; Department of Chemistry, Savitribai Phule Pune University, (Formerly, University of Pune), Pune, 411007, India., Shinde VS; Department of Chemistry, Savitribai Phule Pune University, (Formerly, University of Pune), Pune, 411007, India. Electronic address: vaishali.shinde@unipune.ac.in.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2021 Sep; Vol. 205, pp. 111834. Date of Electronic Publication: 2021 May 11.
DOI: 10.1016/j.colsurfb.2021.111834
Abstrakt: We developed here stimuli responsive curcumin loaded microgels based on Pluronic F-127. These microgels were prepared using coupling reaction between the amine modified Pluronic and EDTA. The microgel exhibited the affinity for hydrophobic drug, curcumin and showed pH as well as temperature-dependent release. Furthermore, the cytotoxicity study demonstrated dose-dependent inhibition of MDA-MB-231 cell growth with the most effective IC 50 value (3.8 ± 0.2 μg mL -1 after 24 h). Based on these findings, the fabricated curcumin loaded microgels offered additional advantages over conventional drug therapies for treatment of cancer.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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