Vitamin D status in Hashimoto's thyroiditis and its association with vitamin D receptor genetic variants.

Autor: Hanna HWZ; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: Hanywilliam@kasralainy.edu.eg., Rizzo C; Clinical Division and Research Unit of Metabolic Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Electronic address: Cristiano.rizzo@opbg.net., Abdel Halim RM; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: radwa.marawan@kasralainy.edu.eg., El Haddad HE; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: Hemmat.elhaddad@gmail.com., Salam R; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: randa.salam@live.com., El-Sayed Abou-Youssef H; Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: hazem2000@kasralainy.edu.eg.
Jazyk: angličtina
Zdroj: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2021 Sep; Vol. 212, pp. 105922. Date of Electronic Publication: 2021 May 17.
DOI: 10.1016/j.jsbmb.2021.105922
Abstrakt: Background: Hashimoto's thyroiditis (HT) is considered the predominant cause of hypothyroidism in iodine sufficient countries. The deficiency of 25-OH-vitamin D3 serum level and the variation of vitamin D receptor (VDR) gene were implicated in a number of autoimmune disorders. This study aimed to test the hypothesis linking between VDR FokI and BsmI variants and HT, in addition to explain their impact on 25-OH-vitamin D3 serum level.
Materials and Methods: Cross sectional study included 160 hypothyroid subjects, 112 patients with HT and 48 hypothyroid non-HT controls. They were diagnosed based on anti-TPO Ab and or anti-TG Ab results. All cases were subjected to full history taking, thyroid ultrasound examination and a panel of assays (TSH, f.T3, f.T4, anti-TPO Ab, anti-TG Ab, calcium, alkaline phosphatase and phosphate). Serum 25-OH-vitamin D3 was assayed using HPLC-UV method. VDR variants (FokI and BsmI) were genotyped using real-time PCR.
Results: FokI AA genotype was statistically higher in HT patients than control group (P value = 0.02) with subsequently higher serum 25-OH-vitamin D3 level in comparison to all other genotypes (P value = 0.039). Serum 25-OH-vitamin D3 level was statistically indifferent between HT and control group (P value = 0.223). A statistically significant increase in total thyroid volume was observed in HT group (P value = 0.002).
Conclusion: FokI AA genotype is more associated with HT in Egyptian patients compared to hypothyroid non-HT controls. Moreover, patients with FokI AA genotype have statistically higher levels of 25-OH-vitamin D3 suggesting VDR dysfunction even in patients expressing normal level of vitamin D.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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