Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review.
| Autor: | Bullington BW; Center for Global Health, Weill Cornell Medicine, New York, NY, United States of America., Klemperer K; London School of Hygiene and Tropical Medicine, London, United Kingdom., Mages K; Samuel J. Wood Library Weill Cornell Medicine, New York, NY, United States of America., Chalem A; Center for Global Health, Weill Cornell Medicine, New York, NY, United States of America., Mazigo HD; Mwanza Intervention Trials Unit, National Institute for Medical Research Mwanza, Tanzania., Changalucha J; Mwanza Intervention Trials Unit, National Institute for Medical Research Mwanza, Tanzania., Kapiga S; Mwanza Intervention Trials Unit, National Institute for Medical Research Mwanza, Tanzania.; Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom., Wright PF; Department of Pediatrics, Dartmouth Geisel School of Medicine, Hanover, New Hampshire, United States of America., Yazdanbakhsh MM; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands., Downs JA; Center for Global Health, Weill Cornell Medicine, New York, NY, United States of America. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | PLoS pathogens [PLoS Pathog] 2021 May 20; Vol. 17 (5), pp. e1009555. Date of Electronic Publication: 2021 May 20 (Print Publication: 2021). |
| DOI: | 10.1371/journal.ppat.1009555 |
| Abstrakt: | Although a growing number of studies suggest interactions between Schistosoma parasites and viral infections, the effects of schistosome infections on the host response to viruses have not been evaluated comprehensively. In this systematic review, we investigated how schistosomes impact incidence, virulence, and prevention of viral infections in humans and animals. We also evaluated immune effects of schistosomes in those coinfected with viruses. We screened 4,730 studies and included 103. Schistosomes may increase susceptibility to some viruses, including HIV and Kaposi's sarcoma-associated herpesvirus, and virulence of hepatitis B and C viruses. In contrast, schistosome infection may be protective in chronic HIV, Human T-cell Lymphotropic Virus-Type 1, and respiratory viruses, though further research is needed. Schistosome infections were consistently reported to impair immune responses to hepatitis B and possibly measles vaccines. Understanding the interplay between schistosomes and viruses has ramifications for anti-viral vaccination strategies and global control of viral infections. Competing Interests: The authors have declared that no competing interests exist. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|