Potent Antihyperuricemic Triterpenoids Based on Two Unprecedented Scaffolds from the Leaves of Alstonia scholaris .

Autor: Hu BY; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., Zhao YL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201, P. R. China., Xiong DS; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., He YJ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., Zhou ZS; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., Zhu PF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201, P. R. China., Wang ZJ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., Wang YL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., Zhao LX; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China., Luo XD; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Nature Products, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201, P. R. China.
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2021 Jun 04; Vol. 23 (11), pp. 4158-4162. Date of Electronic Publication: 2021 May 20.
DOI: 10.1021/acs.orglett.1c01102
Abstrakt: Two rearranged triterpenoids, representing new subtypes of pentacyclic triterpenoids, with unique 6/6/6/7/5 and 6/6/5/6/6/6 ring systems were isolated from Alstonia scholaris . Their structures were established by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Both compounds exhibited potent antihyperuricemic bioactivity in vitro and in vivo .
Databáze: MEDLINE
Externí odkaz: