Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

Autor:	Seymen-Karabulut G; University of Health Sciences Turkey, Ümraniye Training and Research Hospital, Clinic of Pediatrics, Division of Pediatric Endocrinology, İstanbul, Turkey, Günlemez A; Kocaeli University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Kocaeli, Turkey, Gökalp AS; Kocaeli University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Kocaeli, Turkey, Hatun Ş; Koç University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, İstanbul, Turkey, Kaya Narter F; Dr. Lütfi Kırdar Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, İstanbul, Turkey, Mutlu M; Karadeniz Technical University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Trabzon, Turkey, Kader Ş; Trabzon Kanuni Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Trabzon, Turkey, Terek D; Ege University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, İzmir, Turkey, Hanta D; Adana Women and Children Hospital, Clinic of Pediatrics, Division of Neonatology, Adana, Turkey, Okulu E; Ankara University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, Turkey, Karadeniz L; University of Health Sciences Turkey, Ümraniye Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, İstanbul, Turkey, Kanmaz Kutman HG; Zekai Tahir Burak Maternity Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Ankara, Turkey, Zenciroğlu A; University of Health Sciences Turkey, Ankara Dr. Sami Ulus Maternity Women and Children Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Ankara, Turkey, Özdemir ÖMA; Pamukkale University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Denizli, Turkey, Sarıcı D; Keçiören Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Ankara, Turkey, Çelik M; Diyarbakır Children Hospital, Clinic of Pediatrics, Division of Neonatology, Diyarbakır, Turkey, Demir N; Van Yüzüncü Yıl University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Van, Turkey, Turan Ö; Başkent University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, Turkey, Çelik K; Dr. Behçet Uz Children Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, İzmir, Turkey, Kılıçbay F; Kocaeli University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Kocaeli, Turkey, Uslu S; Şişli Hamidiye Etfal Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, İstanbul, Turkey, Erol S; Etlik Zübeyde Hanım Maternity Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Ankara, Turkey, Ertuğrul S; Dicle University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Diyarbakır, Turkey, Er İ; Derince Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Kocaeli, Turkey, Çelik HT; acettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, Turkey, Çetinkaya M; Kanuni Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, İstanbul, Turkey, Aktürk-Acar F; Karadeniz Technical University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Trabzon, Turkey, Aslan Y; Trabzon Kanuni Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, Trabzon, Turkey, Tunç G; Ankara University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, Turkey, Güran Ö; University of Health Sciences Turkey, Ümraniye Training and Research Hospital, Clinic of Pediatrics, Division of Neonatology, İstanbul, Turkey, Engin Arısoy A; Kocaeli University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Kocaeli, Turkey
Jazyk:	angličtina
Zdroj:	Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2021 Nov 25; Vol. 13 (4), pp. 384-390. Date of Electronic Publication: 2021 May 20.
DOI:	10.4274/jcrpe.galenos.2020.2021.0169
Abstrakt:	Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns. Methods: Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels. Results: The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients. Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.
Databáze:	MEDLINE
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