Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein.

Autor: Lapidus S; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Liu F; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Casanovas-Massana A; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Dai Y; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Huck JD; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Lucas C; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Klein J; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Filler RB; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA.; Yale School of Medicine, Department of Laboratory Medicine, New Haven, CT, 06510, USA., Strine MS; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA.; Yale School of Medicine, Department of Laboratory Medicine, New Haven, CT, 06510, USA., Sy M; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Deme AB; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Badiane AS; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Dieye B; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Ndiaye IM; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Diedhiou Y; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Mbaye AM; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Diagne CT; DiaTROPIX Rapid Diagnostic Tests Facility, Institut Pasteur de Dakar, Dakar, Senegal., Vigan-Womas I; Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Mbengue A; G4 - Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Sadio BD; Pôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal., Diagne MM; Pôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal., Moore AJ; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Mangou K; G4 - Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Diallo F; G4 - Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Sene SD; G4 - Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Pouye MN; G4 - Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Faye R; Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Diouf B; Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal., Nery N Jr; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil., Costa F; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA.; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil., Reis M; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA.; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil., Muenker MC; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Hodson DZ; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Mbarga Y; Douala Military Hospital, Douala, Cameroon., Katz BZ; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago., Andrews JR; Division of Infectious Diseases and Geographic Medicine, School of Medicine, Stanford University, Stanford, CA, USA., Campbell M; Yale Center for Clinical Investigation, Yale School of Medicine, New Haven, Connecticut, USA., Srivathsan A; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Kamath K; Serimmune, Inc., Goleta, CA., Baum-Jones E; Serimmune, Inc., Goleta, CA., Faye O; Pôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal., Sall AA; Pôle Virologie, Institut Pasteur de Dakar, Dakar, Senegal., Quintero Vélez JC; Grupo de Investigación Ciencias Veterinarias Centauro, Universidad de Antioquia, Medellin, Colombia.; Grupo de Investigación Ciencias Veterinarias Centauro, University of Antioquia, Medellín, Colombia.; Grupo de Investigación Microbiología Básica y Aplicada, University of Antioquia, Medellín, Colombia., Cappello M; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA., Wilson M; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana., Ben-Mamoun C; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Somé FA; Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso., Dabiré RK; Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso., Moukoko CEE; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, BP 2701 Douala, Cameroon.; Malaria Research Unit, Center Pasteur Cameroon, Yaoundé, Cameroon., Ouédraogo JB; Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso., Boum Y 2nd; University of Yaoundé and Epicentre, Médecins Sans Frontières., Shon J; Serimmune, Inc., Goleta, CA., Ndiaye D; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal., Wisnewski A; Yale Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Parikh S; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA., Iwasaki A; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Wilen CB; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Ko AI; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil., Ring AM; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA., Bei AK; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA.; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal.; G4 - Malaria Experimental Genetic Approaches & Vaccines, Pôle Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal.
Jazyk: angličtina
Zdroj: MedRxiv : the preprint server for health sciences [medRxiv] 2021 May 12. Date of Electronic Publication: 2021 May 12.
DOI: 10.1101/2021.05.10.21256855
Abstrakt: Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.
Databáze: MEDLINE