Epidemiology and genetic characterization of respiratory syncytial virus in children with acute respiratory infections: Findings from the influenza sentinel surveillance network in Central African Republic, 2015 to 2018.

Autor: Komoyo GF; Laboratoire des arbovirus, des fièvres hémorragiques virales, des virus émergents et des zoonoses Institut Pasteur de Bangui Bangui Central African Republic.; Ecole Doctorale d'Infectiologie Tropicale de Franceville, Gabon Franceville Gabon., Yambiyo BM; Service d'épidémiologie Institut Pasteur de Bangui Bangui Central African Republic., Manirakiza A; Service d'épidémiologie Institut Pasteur de Bangui Bangui Central African Republic., Gody JC; Complexe pédiatrique de Bangui Centre National Hospitalier Universitaire de Bangui Bangui Central African Republic., Muller CP; Clinical and Applied Virology group, Department of Infection and Immunity Luxembourg Institute of Health Esch-sur-Alzette Luxembourg., Hübschen JM; Clinical and Applied Virology group, Department of Infection and Immunity Luxembourg Institute of Health Esch-sur-Alzette Luxembourg., Nakoune E; Laboratoire des arbovirus, des fièvres hémorragiques virales, des virus émergents et des zoonoses Institut Pasteur de Bangui Bangui Central African Republic., Snoeck CJ; Clinical and Applied Virology group, Department of Infection and Immunity Luxembourg Institute of Health Esch-sur-Alzette Luxembourg.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2021 May 11; Vol. 4 (2), pp. e298. Date of Electronic Publication: 2021 May 11 (Print Publication: 2021).
DOI: 10.1002/hsr2.298
Abstrakt: Background and Aims: Respiratory syncytial virus (RSV) is one of the main viral pathogens causing acute respiratory infections in children under 5 years of age but has seldom been studied in Central African Republic (CAF). Taking advantage of the national influenza surveillance network in CAF, this study aimed at providing the first insights into RSV prevalence and seasonality over 4 years of surveillance and the clinical manifestations of RSV in this population in CAF.
Methods: A total of 3903 children under 5 years matching the influenza-like illness (ILI, 68.5%) or severe acute respiratory infection (SARI, 31.5%) case definitions were recruited from January 2015 to December 2018. The presence of RSV viral RNA in nasopharyngeal samples was assessed by RT-PCR, followed by RSV-A and RSV-B typing and Sanger sequencing on a subset of samples. Phylogenetic analyses were carried on partial G protein sequences. Associations between RSV and demographic or clinical manifestations were investigated by statistical analyses.
Results: RSV prevalence was significantly higher in infants <6 months (13.4%), in hospitalized children (13.3% vs 5.5%) and in male patients (9.5% vs 6.4%). An overall prevalence of RSV of 8.0% in the period of 2015 to 2018 was shown, with significant annual (6.4%-10.6%) and seasonal (12.7% in rainy season vs 3.0% in dry season) fluctuations. While RSV seasons in 2015, 2016, and 2018 were relatively similar, 2017 showed deviations from the overall patterns with significantly higher RSV circulation and an outbreak peak 3 to 5 months earlier. Concomitant circulation of RSV-A and RSV-B with an alternating predominance of RSV-A and RSV-B strains and temporal RSV-A genotype replacement from NA1 to ON1 was observed.
Conclusion: This study represents the first in-depth epidemiological analysis of RSV in CAF and provides first insights into RSV genetic diversity and seasonality in the country.
Competing Interests: The authors declare that they have no conflict of interests.
(© 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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