Demographic and clinical patterns of severe asthma in the Middle East.

Autor: Abuzakouk M; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Ghorab OKHA; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Mahboub B; Department of Pulmonary Medicine, Rashid Hospital, Dubai, UAE., Alzaabi A; Division of Respiratory Medicine, Zayed Military Hospital, Abu Dhabi, UAE., Uzbeck MH; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Nasir M; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Zoumot Z; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Grandon D; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., El Sameed YA; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Namas R; Cleveland Clinic, Medical Sub-Specialties Institute, Abu Dhabi, UAE., Wahla AS; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Chapman J; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Saleh K; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Salvo F; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Bodi GS; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE., Shafiq I; Cleveland Clinic, Respiratory and Allergy Institute, Abu Dhabi, UAE.
Jazyk: angličtina
Zdroj: Annals of thoracic medicine [Ann Thorac Med] 2021 Apr-Jun; Vol. 16 (2), pp. 172-177. Date of Electronic Publication: 2021 Apr 17.
DOI: 10.4103/atm.ATM_131_20
Abstrakt: Background: Severe asthma is a major burden on health-economic resources; hence, knowing the epidemiology of these patients is important in planning and provision of asthma care. In addition, identifying and managing the comorbidities helps improve symptoms and reduce associated morbidity and mortality.
Objectives: Epidemiology of difficult asthma has not been well studied in the Middle East, so in this study, we present the demographic and clinical characteristics of severe asthma in the United Arab Emirates (UAE).
Methods: We retrospectively reviewed the notes of severe asthma patients attending three tertiary care hospitals between May 2015 and December 2019. Data on baseline demographics, asthma characteristics, treatment, and comorbidities were collected.
Results: We reviewed the notes of 458 patients (271 females and 187 males) that fulfilled the 2019 Global Initiative for Asthma guidelines for the diagnosis of severe asthma. The mean age was 47.7 (standard deviation 17.2) years. Males had significantly higher asthma control test scores (17.9 vs. 16, P = 0.01) and mean blood eosinophils (0.401 vs. 0.294, P <0.01) than females. The most common comorbidity observed was allergic rhinitis (52.2%) followed by gastroesophageal reflux disease (27.1%). In total, 109 (23.8%) patients were on biological therapies with most patients being on omalizumab and dupilumab (29 and 18 patients, respectively). Most patients were nonsmokers (97.2%), and majority were of TH2-high phenotype (75.7%).
Conclusions: In this first report of severe asthma characteristics in the UAE, we found a pattern of female preponderance and most patients having a Th2-high phenotype. The findings are likely to help optimize asthma care in the region in the era of biologic therapies.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2021 Annals of Thoracic Medicine.)
Databáze: MEDLINE
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