Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies.

Autor:	Abubakar MB; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria., Usman D; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria., El-Saber Batiha G; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt., Cruz-Martins N; Faculty of Medicine, University of Porto, Porto, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal.; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal., Malami I; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria., Ibrahim KG; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria., Abubakar B; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria., Bello MB; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.; Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria., Muhammad A; Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna Sate, Nigeria., Gan SH; School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia., Dabai AI; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.; Department of Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria., Alblihed M; Department of Microbiology, College of Medicine, Taif University, Taif, Saudi Arabia., Ghosh A; Microbiology Division, Department of Botany, Gauhati University, Guwahati, India., Badr RH; Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt., Thangadurai D; Department of Botany, Karnatak University, Dharwad, India., Imam MU; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University, Sokoto, Nigeria.; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2021 May 03; Vol. 12, pp. 629935. Date of Electronic Publication: 2021 May 03 (Print Publication: 2021).
DOI:	10.3389/fphar.2021.629935
Abstrakt:	The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and readily available are desired, but lacking. Nevertheless, the pandemic is noticeably of lesser burden in African and Asian regions, where the use of traditional herbs predominates, with such relationship warranting a closer look at ethnomedicine. From a molecular viewpoint, the interaction of SARS-CoV-2 with angiotensin converting enzyme 2 (ACE2) is the crucial first phase of COVID-19 pathogenesis. Here, we review plants with medicinal properties which may be implicated in mitigation of viral invasion either via direct or indirect modulation of ACE2 activity to ameliorate COVID-19. Selected ethnomedicinal plants containing bioactive compounds which may prevent and mitigate the fusion and entry of the SARS-CoV-2 by modulating ACE2-associated up and downstream events are highlighted. Through further experimentation, these plants could be supported for ethnobotanical use and the phytomedicinal ligands could be potentially developed into single or combined preventive therapeutics for COVID-19. This will benefit researchers actively looking for solutions from plant bioresources and help lessen the burden of COVID-19 across the globe. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Abubakar, Usman, El-Saber Batiha, Cruz-Martins, Malami, Ibrahim, Abubakar, Bello, Muhammad, Gan, Dabai, Alblihed, Ghosh, Badr, Thangadurai and Imam.)
Databáze:	MEDLINE
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