Is climacterium by the mid-40s associated with thyroid dysfunction or autoimmunity? A population-based study.

Autor:	Savukoski SM; Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Niinimäki MJ; Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Pesonen PRO; Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Auvinen JP; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Centre for Life Course Health Research, University of Oulu, Oulu, Finland., Männistö T; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; NordLab Oulu, Oulu University Hospital, Oulu, Finland.; Department of Clinical Chemistry, University of Oulu, Oulu, Finland., Puukka KS; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; NordLab Oulu, Oulu University Hospital, Oulu, Finland.; Department of Clinical Chemistry, University of Oulu, Oulu, Finland., Ebeling T; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Internal Medicine, Oulu University Hospital and University of Oulu, OYS, Finland., Suvanto ETJ; Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Finland.; Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jazyk:	angličtina
Zdroj:	Menopause (New York, N.Y.) [Menopause] 2021 May 17; Vol. 28 (9), pp. 1053-1059. Date of Electronic Publication: 2021 May 17.
DOI:	10.1097/GME.0000000000001800
Abstrakt:	Objective: We investigated whether more advanced climacteric stage in the mid-40s is associated with thyroid autoimmunity and dysfunction. Methods: This cross-sectional cohort study included 2,569 46-year-old women. Thyroid hormone, thyroid peroxidase antibodies, and follicle-stimulating hormone levels were determined. Using menstrual history and follicle-stimulating hormone levels, the participants were divided into climacteric (n = 340) and preclimacteric (n = 2,229) groups. Women diagnosed with premature ovarian insufficiency (menopause by 40 y of age) were excluded. The use of thyroid medication was evaluated from the medication reimbursement register. The prevalence of thyroid medication use, laboratory-based thyroid dysfunction, and thyroid peroxidase antibody positivity was compared between the two groups. The association between climacteric status and thyroid disorders was investigated using a logistic regression model including smoking and thyroid antibody status. Results: At 46 years old, climacteric women used thyroid medication more often than preclimacteric women (9.1% vs 6.1%; P = 0.04). There was no difference in the prevalence of subclinical or clinical hypothyroidism and hyperthyroidism in nonmedicated participants (5.5% vs 5.0%; P = 0.7) or thyroid peroxidase antibody positivity (14.0% vs 15.0%, P = 0.7). In the regression model, being climacteric (OR = 1.6; 95% CI 1.1-2.3; P = 0.02) and antibody positivity (OR 4.9; 95% CI 3.6-6.6; P < 0.001) were associated with a higher prevalence of thyroid dysfunction. Conclusions: More advanced climacteric stage in the mid-40s was slightly associated with thyroid dysfunction but not thyroid autoimmunity. Competing Interests: Financial disclosure/conflicts of interest: T.M. has received speaker fees from Labquality, Inc. The other authors have nothing to disclose. (Copyright © 2021 by The North American Menopause Society.)
Databáze:	MEDLINE
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