Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.

Autor: Raber J; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA.; Departments of Neurology, Psychiatry, and Radiation Medicine, Division of Neuroscience ONPRC, Oregon Health & Science University, Portland, Oregon, USA.; College of Pharmacy, Oregon State University, Corvallis, Oregon, USA., Perez R; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Torres ERS; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Krenik D; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Boutros S; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Patel E; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Chlebowski AC; Department of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, Oregon, USA., Torres ER; Department of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, Oregon, USA., Perveen Z; Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Penn A; Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Paulsen DB; Department of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Bartlett MG; University of Georgia, College of Pharmacy, Athens, Georgia, USA., Jia E; University of Georgia, College of Pharmacy, Athens, Georgia, USA., Holden S; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Hall R; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA., Morré J; Mass Spectrometry Core, Oregon State University, Corvallis, Oregon, USA., Wong C; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA.; Department of Animal Sciences, Oregon State University, Corvallis, Oregon, USA., Ho E; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA.; College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon, USA., Choi J; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA., Stevens JF; College of Pharmacy, Oregon State University, Corvallis, Oregon, USA.; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA., Noël A; Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA., Bobe G; Mass Spectrometry Core, Oregon State University, Corvallis, Oregon, USA.; Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA., Kisby G; Department of Basic Medical Sciences, Western University of Health Sciences, College of Osteopathic Medicine of the Pacific Northwest, Lebanon, Oregon, USA.
Jazyk: angličtina
Zdroj: Environmental health perspectives [Environ Health Perspect] 2021 May; Vol. 129 (5), pp. 57009. Date of Electronic Publication: 2021 May 19.
DOI: 10.1289/EHP8428
Abstrakt: Background: Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at an early age (3-4 months) and in which tau dysregulation and neuronal loss correlate with synaptic dysfunction and cognitive decline.
Objective: The goal of this study was to assess the effects of chronic SHS exposure (10 months' exposure to ∼ 30   mg / m 3 ) on behavioral and cognitive function, metabolism, and neuropathology in mice.
Methods: Wild-type (WT) and htau female and male mice were exposed to SHS (90% side stream, 10% main stream) using the SCIREQ® inExpose™ system or air control for 168 min per day, for 312 d, 7 d per week. The exposures continued during the days of behavioral and cognitive testing. In addition to behavioral and cognitive performance and neuropathology, the lungs of mice were examined for pathology and alterations in gene expression.
Results: Mice exposed to chronic SHS exposure showed the following genotype-dependent responses: a ) lower body weights in WT, but not htau, mice; b ) less spontaneous alternation in WT, but not htau, mice in the Y maze; c ) faster swim speeds of WT, but not htau, mice in the water maze; d ) lower activity levels of WT and htau mice in the open field; e ) lower expression of brain PHF1, TTCM1, IGF 1 β , and HSP90 protein levels in WT male, but not female, mice; and f ) more profound effects on hippocampal metabolic pathways in WT male than female mice and more profound effects in WT than htau mice.
Discussion: The brain of WT mice, in particular WT male mice, might be especially susceptible to the effects of chronic SHS exposure. In WT males, independent pathways involving ascorbate, flavin adenine dinucleotide, or palmitoleic acid might contribute to the hippocampal injury following chronic SHS exposure. https://doi.org/10.1289/EHP8428.
Databáze: MEDLINE
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