Temporal Analysis of Tachycardia During Catheter Directed Thrombolysis for Acute Pulmonary Embolism.

Autor:	Graif A; Department of Vascular and Interventional Radiology, Christiana Care, Newark, DE, USA., Grilli CJ; Department of Vascular and Interventional Radiology, Christiana Care, Newark, DE, USA., Scott AL; Department of Radiology, Einstein Medical Center Montgomery, East Norriton, PA, USA., Patel KD; Department of Vascular and Interventional Radiology, Christiana Care, Newark, DE, USA., Zimmermann TJ; Department of Vascular and Interventional Radiology, Christiana Care, Newark, DE, USA., Wimmer NJ; Department of Cardiology, Christiana Care, Newark, DE, USA., Kimbiris G; Department of Vascular and Interventional Radiology, Christiana Care, Newark, DE, USA., Leung DA; Department of Vascular and Interventional Radiology, Christiana Care, Newark, DE, USA.
Jazyk:	angličtina
Zdroj:	Vascular and endovascular surgery [Vasc Endovascular Surg] 2021 Oct; Vol. 55 (7), pp. 689-695. Date of Electronic Publication: 2021 May 19.
DOI:	10.1177/15385744211017109
Abstrakt:	Purpose: To evaluate the effect of catheter directed thrombolysis (CDT) on heart rate (HR) in patients with sinus tachycardia and acute pulmonary embolism (PE). Methods: A retrospective chart review was performed for patients who underwent CDT with tPA for acute massive or submassive PE between 12/2009 and 2/2020. Included were patients who presented with tachycardia at the time of initiation of CDT. Patients with chronic PE, atrial fibrillation, beta blocker therapy, adjunctive endovascular therapy, systemic thrombolysis, or who expired before conclusion of CDT were excluded. HR was measured approximately every hour during CDT. Graphs were plotted of HR as a function of CDT duration. Two interventional radiologists identified the point of plateau (POP) on the graph where CDT had maximized its benefit in decreasing the patient's HR. Discrepancies were adjudicated by a third interventional radiologist and the median of the 3 measurements was selected. The primary endpoint was the duration of CDT from initiation until the POP. Results: 48 patients were included (52.5 ± 14.7 years, 56.3% female). The POP occurred after 13.1 ± 6.1 hours, by which point HR had been reduced from 110 ± 9.2 bpm to 88 ± 10.6 bpm. Sinus tachycardia was not resolved in 10 patients even though they achieved maximal improvement in HR after 11.3 ± 6.7 hours. Conclusion: Patients presenting with sinus tachycardia related to acute PE achieved maximal, sustained reduction in heart rate from CDT, after approximately 13 hours of infusion. Patients who did not resolve their tachycardia by that point in time were unlikely to resolve it by the conclusion of CDT.
Databáze:	MEDLINE
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