Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus).

Autor: Laffitte A; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK., Gibbs M; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK., Hernangomez de Alvaro C; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK., Addison J; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK., Lonsdale ZN; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK., Giribaldi MG; IMAX Discovery GmbH, Otto-Hahn-Straße 15, 44227, Dortmund, Germany.; AXXAM S.p.A., OpenZone, Via Meucci 3, 20091, Bresso, Milan, Italy., Rossignoli A; IMAX Discovery GmbH, Otto-Hahn-Straße 15, 44227, Dortmund, Germany.; AXXAM S.p.A., OpenZone, Via Meucci 3, 20091, Bresso, Milan, Italy., Vennegeerts T; IMAX Discovery GmbH, Otto-Hahn-Straße 15, 44227, Dortmund, Germany.; AXXAM S.p.A., OpenZone, Via Meucci 3, 20091, Bresso, Milan, Italy., Winnig M; IMAX Discovery GmbH, Otto-Hahn-Straße 15, 44227, Dortmund, Germany.; AXXAM S.p.A., OpenZone, Via Meucci 3, 20091, Bresso, Milan, Italy., Klebansky B; BioPredict, Inc., 4 Adele Avenue, Demarest, NJ, 07627, USA., Skiles J; BioPredict, Inc., 4 Adele Avenue, Demarest, NJ, 07627, USA.; Valis Pharma, Ins., 545 Bonair Way, La Jolla, CA, 92037, USA., Logan DW; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK., McGrane SJ; WALTHAM Petcare Science Institute, Freeby Lane, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT, UK. scott.mcgrane@effem.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 May 18; Vol. 11 (1), pp. 10527. Date of Electronic Publication: 2021 May 18.
DOI: 10.1038/s41598-021-89558-w
Abstrakt: Kokumi taste is a well-accepted and characterised taste modality and is described as a sensation of enhancement of sweet, salty, and umami tastes. The Calcium Sensing Receptor (CaSR) has been designated as the putative kokumi taste receptor for humans, and a number of kokumi-active ligands of CaSR have been discovered recently with activity confirmed both in vivo and in vitro. Domestic cats (Felis catus) are obligate carnivores and accordingly, their diet is abundant in proteins, peptides, and amino acids. We hypothesised that CaSR is a key taste receptor for carnivores, due to its role in the detection of different peptides and amino acids in other species. Using in silico, in vitro and in vivo approaches, here we compare human CaSR to that of a model carnivore, the domestic cat. We found broad similarities in ligand specificity, but differences in taste sensitivity between the two species. Indeed our in vivo data shows that cats are sensitive to CaCl 2 as a kokumi compound, but don't show this same activity with Glutathione, whereas for humans the reverse is true. Collectively, our data suggest that kokumi is an important taste modality for carnivores that drives the palatability of meat-derived compounds such as amino acids and peptides, and that there are differences in the perception of kokumi taste between carnivores and omnivores.
Databáze: MEDLINE
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