Flavonolignan 2, 3-dehydroderivatives from Oenanthe javanica and their anti inflammatory activities.

Autor: Wei RR; Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine & Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P. R. China., Ma QG; Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine & Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P. R. China.
Jazyk: angličtina
Zdroj: Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2021 May 18; Vol. 76 (11-12), pp. 459-465. Date of Electronic Publication: 2021 May 18 (Print Publication: 2021).
DOI: 10.1515/znc-2021-0001
Abstrakt: Flavonolignans, for example, silymarin and silybin, have interesting biological activities. For the first time, three new flavonolignans named oenanthenoid A-C ( 1 - 3 ) and nine known flavonolignan derivatives ( 4 - 12 ) were isolated from Oenanthe javanica . Comprehensive spectroscopic data analysis and references were used to identify all of the compounds. The anti inflammatory activities of these isolates ( 1 - 12 ) on RAW264.7 macrophage cells were investigated. Three new compounds ( 1 - 3 ) demonstrated anti inflammatory activity with IC 50 values ranging from 6.5 ± 0.6 to 14.7 ± 1.6 µM. Furthermore, two compounds ( 11 and 12 ) demonstrated moderate anti inflammatory activity, with IC 50 values ranging from 24.1 ± 1.2 to 62.5 ± 1.9 µM.
(© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze: MEDLINE