Sarcopenia and mortality in different clinical conditions: A meta-analysis.

Autor:	Koon-Yee Lee G; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong., Chun-Ming Au P; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong., Hoi-Yee Li G; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong., Chan M; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Li HL; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Man-Yung Cheung B; Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Chi-Kei Wong I; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong., Ho-Fun Lee V; Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong., Mok J; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Hon-Kei Yip B; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong., King-Yip Cheng K; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong., Wu CH; Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.; Institute of Geriatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Cheung CL; Department of Pharmacology and Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong.
Jazyk:	angličtina
Zdroj:	Osteoporosis and sarcopenia [Osteoporos Sarcopenia] 2021 Mar; Vol. 7 (Suppl 1), pp. S19-S27. Date of Electronic Publication: 2021 Mar 11.
DOI:	10.1016/j.afos.2021.02.001
Abstrakt:	Objectives: Sarcopenia is recognized to be a health problem which is as serious as obesity, but its relevance to mortality is unclear. We conducted a meta-analysis of cohort studies on lean mass and mortality in populations with different health conditions. Methods: In this study, a systematic search of PubMed, Cochrane Library and Embase was performed for cohort studies published before Dec 20, 2017 which examined the relationship between lean mass and mortality. We included studies reporting lean mass measurement by dual-energy X-ray absorptiometry, bioimpedance analysis or computed tomography, as continuous (per standard deviation [SD] decrease) or binary variables (using sarcopenia cutoffs). We excluded studies which used muscle mass surrogates, anthropometric measurement of muscle, rate of change in muscle mass, and sarcopenia defined by composite criteria. The primary study outcome was all-cause mortality. Pooled hazard ratio estimates were calculated using a random effects model. Results: A total of 9602 articles were identified from the systematic search, and 188 studies with 98 468 participants from 34 countries were included in the meta-analysis. Of the 68 studies included in the present meta-analysis, the pooled HR was 1.36 and 1.74 for every SD decrease in lean mass and in people with low lean mass (cutoffs), respectively. Significant associations were also observed in elderly and all disease subgroups, irrespective of the measurement modalities. Conclusions: Lower lean mass is robustly associated with increased mortality, regardless of health conditions and lean mass measurement modalities. This meta-analysis highlighted low lean mass as a key public health issue. Competing Interests: The authors declare no competing interests. (© 2021 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V.)
Databáze:	MEDLINE
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