Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1).

Autor:	Choreño-Parra JA; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Jiménez-Álvarez LA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Cruz-Lagunas A; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Rodríguez-Reyna TS; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Ramírez-Martínez G; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Sandoval-Vega M; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Mexico City, Mexico., Hernández-García DL; Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Choreño-Parra EM; Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City, Mexico., Balderas-Martínez YI; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Martinez-Sánchez ME; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Márquez-García E; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Sciutto E; Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico., Moreno-Rodríguez J; Direccion de Enseñanza e Investigación, Hospital Juárez de Mexico, Mexico City, Mexico., Barreto-Rodríguez JO; Subdirección de Medicina, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Vázquez-Rojas H; Subdirección de Medicina, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Centeno-Sáenz GI; Subdirección de Medicina, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Alvarado-Peña N; Coordinación de Infectología y Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Salinas-Lara C; Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía 'Manuel Velasco Suarez', Mexico City, Mexico., Sánchez-Garibay C; Departamento de Neuropatología, Instituto Nacional de Neurología y Neurocirugía 'Manuel Velasco Suarez', Mexico City, Mexico., Galeana-Cadena D; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Hernández G; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Mendoza-Milla C; Departamento de Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Domínguez A; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico., Granados J; Department of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Mena-Hernández L; Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Pérez-Buenfil LÁ; Department of Education, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Domínguez-Cheritt G; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.; Critical Care Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Cabello-Gutiérrez C; Department of Virology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Luna-Rivero C; Department of Pathology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Salas-Hernández J; General Direction, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Santillán-Doherty P; Department of Medical Direction, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Regalado J; Department of Medical Direction, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Hernández-Martínez A; Laboratorio Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Orozco L; Laboratorio Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Ávila-Moreno F; Biomedicine Research Unit (UBIMED), Lung Diseases and Cancer Epigenomics Laboratory, Facultad de Estudios Superiores (FES) Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla de Baz, Mexico., García-Latorre EA; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico., Hernández-Cárdenas CM; Intensive Care Unit, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico., Khader SA; Department of Molecular Microbiology, Washington University School of Medicine in St Louis, St Louis, MO, United States., Zlotnik A; Department of Physiology & Biophysics School of Medicine, Institute for Immunology, University of California, Irvine, CA, United States., Zúñiga J; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Apr 21; Vol. 12, pp. 593595. Date of Electronic Publication: 2021 Apr 21 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.593595
Abstrakt:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is a global health threat with the potential to cause severe disease manifestations in the lungs. Although COVID-19 has been extensively characterized clinically, the factors distinguishing SARS-CoV-2 from other respiratory viruses are unknown. Here, we compared the clinical, histopathological, and immunological characteristics of patients with COVID-19 and pandemic influenza A(H1N1). We observed a higher frequency of respiratory symptoms, increased tissue injury markers, and a histological pattern of alveolar pneumonia in pandemic influenza A(H1N1) patients. Conversely, dry cough, gastrointestinal symptoms and interstitial lung pathology were observed in COVID-19 cases. Pandemic influenza A(H1N1) was characterized by higher levels of IL-1RA, TNF-α, CCL3, G-CSF, APRIL, sTNF-R1, sTNF-R2, sCD30, and sCD163. Meanwhile, COVID-19 displayed an immune profile distinguished by increased Th1 (IL-12, IFN-γ) and Th2 (IL-4, IL-5, IL-10, IL-13) cytokine levels, along with IL-1β, IL-6, CCL11, VEGF, TWEAK, TSLP, MMP-1, and MMP-3. Our data suggest that SARS-CoV-2 induces a dysbalanced polyfunctional inflammatory response that is different from the immune response against pandemic influenza A(H1N1). Furthermore, we demonstrated the diagnostic potential of some clinical and immune factors to differentiate both diseases. These findings might be relevant for the ongoing and future influenza seasons in the Northern Hemisphere, which are historically unique due to their convergence with the COVID-19 pandemic. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer (MC) has declared a shared affiliation, with no collaboration with the author (SK), to the handling editor, at the time of review. (Copyright © 2021 Choreño-Parra, Jiménez-Álvarez, Cruz-Lagunas, Rodríguez-Reyna, Ramírez-Martínez, Sandoval-Vega, Hernández-García, Choreño-Parra, Balderas-Martínez, Martinez-Sánchez, Márquez-García, Sciutto, Moreno-Rodríguez, Barreto-Rodríguez, Vázquez-Rojas, Centeno-Sáenz, Alvarado-Peña, Salinas-Lara, Sánchez-Garibay, Galeana-Cadena, Hernández, Mendoza-Milla, Domínguez, Granados, Mena-Hernández, Pérez-Buenfil, Domínguez-Cheritt, Cabello-Gutiérrez, Luna-Rivero, Salas-Hernández, Santillán-Doherty, Regalado, Hernández-Martínez, Orozco, Ávila-Moreno, García-Latorre, Hernández-Cárdenas, Khader, Zlotnik and Zúñiga.)
Databáze:	MEDLINE
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