Pharmacological Benefits of Triphala: A Perspective for Allergic Rhinitis.

Autor:	Jantrapirom S; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Drosophila Center for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai, University, Chiang Mai, Thailand., Hirunsatitpron P; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Graduate School, Chiang Mai University, Chiang Mai, Thailand., Potikanond S; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Nimlamool W; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Hanprasertpong N; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2021 Apr 30; Vol. 12, pp. 628198. Date of Electronic Publication: 2021 Apr 30 (Print Publication: 2021).
DOI:	10.3389/fphar.2021.628198
Abstrakt:	Allergic rhinitis (AR) is considered a major nasal condition impacting a large number of people around the world, and it is now becoming a global health problem. Because the underlying mechanisms of AR are complex, the development of single-drug treatment might not be enough to treat a wide spectrum of the disease. Although the standard guidelines classify and provide suitable diagnosis and treatment, the vast majority of people with AR are still without any means of controlling it. Moreover, the benefits of AR drugs are sometimes accompanied by undesirable side effects. Thus, it is becoming a significant challenge to find effective therapies with limited undesirable side effects for a majority of patients suffering from uncontrolled AR. Aller-7/NR-A2, a polyherbal formulation, has revealed promising results in patients by reducing nasal symptoms and eosinophil counts without serious adverse effects. Interestingly, three out of seven of the herbals in the Aller-7/NR-A2 formulation are also found in an Ayurvedic polyherbal formulation known as "Triphala," which is a potential candidate for the treatment of AR. However, there are no current studies that have examined the effects of Triphala on the disease. This review aims to describe the complexity of AR pathophysiology, currently available treatments, and the effects of Triphala on AR in order to help develop it as a promising alternative treatment in the future. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Jantrapirom, Hirunsatitpron, Potikanond, Nimlamool and Hanprasertpong.)
Databáze:	MEDLINE
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