Assessment of fragmented QRS formation and its relationship with left ventricular hypertrophy in nonhypertensive acromegaly patients

Autor: Dural M; Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Yorulmaz G; Department of Endocrinology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Alagüney ES; Department of Endocrinology, Konya Training and Research Hospital, Konya, Turkey., Mert KU; Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Camlı E; Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Kalkan AT; Department of Endocrinology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Akalın A; Department of Endocrinology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Kebapçı MN; Department of Endocrinology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Yılmaz AS; Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Murat S; Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey., Efe FB; Department of Endocrinology, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.
Jazyk: angličtina
Zdroj: Turkish journal of medical sciences [Turk J Med Sci] 2021 Oct 21; Vol. 51 (5), pp. 2437-2444. Date of Electronic Publication: 2021 Oct 21.
DOI: 10.3906/sag-2101-229
Abstrakt: Background/aim: It is known that the presence of fragmented QRS (fQRS) on electrocardiography (ECG) is associated with cardiovascular events. The aim of this study was the evaluation of fQRS formation and its relationship with the left ventricular hypertrophy (LVH) parameters in acromegaly patients.
Materials and Methods: In total, 47 previously diagnosed with non-hypertensive acromegaly patients and 48 control subjects were included in the study. ECG and transthoracic echocardiography (TTE) were performed for each participant. Acromegaly patients were divided into two groups according to the fQRS formation on the ECG. Left ventricular wall thicknesses, and left atrial diameter (LAD), left ventricular mass (LVM), left ventricular mass index (LVMi), and relative wall thickness (RWT) were obtained.
Results: In control group 5 (10.4%) and in acromegaly group 17 (36.2%) patients had fQRS on ECG (p = 0.003). LAD [36.0 (34.0–38.0) vs. 38.0 (35.0–41.0) mm, p < 0.001], LVM [155.27 ± 27.00 vs. 173.0 (153.0–235.0) g, p < 0.001], LVMi [83.12 ± 13.19 vs. 92.0 (83.0–118.0) g/m², p < 0.001] and RWT [0.39 ± 0.03 vs. 0.43 (0.41–0.45), p = 0.001] were significantly higher in patients with acromegaly. Disease duration was significantly higher (11.59 ± 1.3 vs. 8.2 ± 1.8 years, p < 0.001) in the fQRS (+) group. LAD [41.0 (39.0–42.5) vs. 37.0 (34.7–38.0) mm, p < 0.001], LVM [219.0 (160.5–254.5) vs. 164.0 (153.0–188.0) g, p = 0.017], LVMi [117.0 (92.5–128.5) vs. 86.0 (82.0–100.2) g/m², p = 0.013] and RWT [0.44 (0.42–0.49) vs. 0.43 (0.40–0.44), p = 0.037] were significantly higher in fQSR (+) acromegaly patients. In multivariate logistic regression analysis, disease duration (odds ratio: 10.05, 95% CI: 1.099–92.012, p = 0.041) and LAD (odds ratio: 2.19, 95% CI: 1.030–4.660, p = 0.042) were found to be the independent predictors of fQRS formation.
Conclusion: The results of our study revealed that fQRS (+) acromegaly patients had increased LVH parameters compared to fQRS (-) patients.
Competing Interests: All of the authors declare that they have no competing interests. The authors also certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.
(This work is licensed under a Creative Commons Attribution 4.0 International License.)
Databáze: MEDLINE
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