Influence of age on treatment and prognosis of invasive cervical cancer.

Autor: Mancebo G; Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: gmancebo@parcdesalutmar.cat., Miralpeix E; Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain., Solé-Sedeño JM; Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain., Tió G; Department of Obstetrics and Gynecology, Hospital Universitari Josep Trueta, Girona, Spain., Rodrigo-Calvo T; Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain., Lloveras B; Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain., Alameda F; Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
Jazyk: angličtina
Zdroj: European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2021 Jul; Vol. 262, pp. 68-72. Date of Electronic Publication: 2021 May 01.
DOI: 10.1016/j.ejogrb.2021.04.040
Abstrakt: Objective: Invasive cervical cancer is considered a young women's disease, however up to 20 % of cases develop cervical cancer at advanced ages. The aim was to characterize invasive cervical cancer in women aged 65 and older assessing age-specific survival differences.
Study Design: A retrospective study including cervical cancer patients was conducted at Hospital del Mar Barcelona from July-2007 to December-2016. Women were stratified: <65 or ≥65years. Clinical and pathological data were collected. Multivariate analysis was used to compare outcomes. Adjusted hazard ratios with 95 % confidence intervals for disease-free survival, and overall survival were estimated using Cox proportional hazards models.
Results: 124 patients with invasive cervical cancer (n = 87 < 65years and n = 37 ≥ 65years) were included. At diagnosis, 48.3 % of <65years patients were diagnosed at advanced stages, while 64.9 % in ≥65years (p = 0.018). Standard treatment was given to 83.9 % of patients in <65years group compared to 62.2 % in ≥65years (p = 0.015). Disease-free survival and overall survival showed no significant differences between groups. Age ≥65 did not predict worse disease-free survival (HR: 0.3 95 %CI, 0.04-3.1, p = 0.347) or overall survival (HR: 0.82 95 %CI, 0.3-2.3, p = 0.729).
Conclusion: Invasive cervical cancer was diagnosed at advanced stages and was treated less frequently with radical intention in patients ≥65years; overall survival and disease-free survival were similar to those cervical cancer diagnosed at younger ages.
Competing Interests: Declaration of Competing Interest The authors report no declarations of interest.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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