Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.

Autor: Zhang Y; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA., Buckmaster PS; Stanford University, Department of Comparative Medicine, Stanford, CA, USA., Qiu L; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA., Wang J; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA; Department of Radiology, Shandong Medical Imaging Research Institute, Jinan, Shandong 250021, China., Keunen O; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA; Translational Radiomics, Quantitative Biology Unit, Luxembourg Institute of Health, Strassen, Luxembourg., Ghobadi SN; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA., Huang A; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China., Hou Q; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA; Nuclear Medicine Department, Guangdong Provincial People's Hospital, Guangzhou 510080, China., Li N; Department of Radiology, Stanford University, Stanford, CA, USA., Narang S; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA., Habte FG; Department of Radiology, Molecular Imaging Program at Stanford, CA, USA., Bertram EH; Department of Neurology, University of Virginia, Charlottesville, VA, USA., Lee KS; Department of Neuroscience, University of Virginia, Charlottesville, VA, USA; Department of Neurosurgery, and Center for Brain, Immunology, and Glia, School of Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address: ksl3h@virginia.edu., Wintermark M; Department of Radiology, Neuroradiology Division, Stanford University, CA, USA. Electronic address: max.wintermark@gmail.com.
Jazyk: angličtina
Zdroj: Experimental neurology [Exp Neurol] 2021 Sep; Vol. 343, pp. 113761. Date of Electronic Publication: 2021 May 12.
DOI: 10.1016/j.expneurol.2021.113761
Abstrakt: Surgery can be highly effective for treating certain cases of drug resistant epilepsy. The current study tested a novel, non-invasive, surgical strategy for treating seizures in a rat model of temporal lobe epilepsy. The surgical approach uses magnetic resonance-guided, low-intensity focused ultrasound (MRgFUS) in combination with intravenous microbubbles to open the blood-brain barrier (BBB) in a transient and focal manner. During the period of BBB opening, a systemically administered neurotoxin (Quinolinic Acid: QA) that is normally impermeable to the BBB gains access to a targeted area in the brain, destroying neurons where the BBB has been opened. This strategy is termed Precise Intracerebral Non-invasive Guided Surgery (PING). Spontaneous recurrent seizures induced by pilocarpine were monitored behaviorally prior to and after PING or under control conditions. Seizure frequency in untreated animals or animals treated with MRgFUS without QA exhibited expected seizure rate fluctuations frequencies between the monitoring periods. In contrast, animals treated with PING targeting the intermediate-temporal aspect of the hippocampus exhibited substantial reductions in seizure frequency, with convulsive seizures being eliminated entirely in two animals. These findings suggest that PING could provide a useful alternative to invasive surgical interventions for treating drug resistant epilepsy, and perhaps for treating other neurological disorders in which aberrant neural circuitries play a role.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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