| Autor: |
Wang H; The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P. R. China. shunchunwang@126.com and Unilever R&D Colworth, Colworth Science Park, Sharnbrook, Bedford MK44 1LQ, UK. Guoping.Lian@unilever.com., Fowler MI; Unilever R&D Colworth, Colworth Science Park, Sharnbrook, Bedford MK44 1LQ, UK. Guoping.Lian@unilever.com., Messenger DJ; Unilever R&D Colworth, Colworth Science Park, Sharnbrook, Bedford MK44 1LQ, UK. Guoping.Lian@unilever.com., Ordaz-Ortiz JJ; Plant Science Laboratory, Cranfield University, MK43 0AL, UK and National Laboratory of Genomics for Biodiversity, CINVESTAV IPN, 36824 Irapuato, Guanajuato, Mexico., Gu X; Unilever R&D Shanghai, 5/F, 66 Lin Xin Road, Shanghai 200335, P. R. China., Shi S; The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P. R. China. shunchunwang@126.com., Terry LA; Plant Science Laboratory, Cranfield University, MK43 0AL, UK., Berry MJ; Unilever R&D Colworth, Colworth Science Park, Sharnbrook, Bedford MK44 1LQ, UK. Guoping.Lian@unilever.com., Lian G; Unilever R&D Colworth, Colworth Science Park, Sharnbrook, Bedford MK44 1LQ, UK. Guoping.Lian@unilever.com and Department of Chemical and Process Engineering, University of Surrey, Guildford, GU2 7XH, UK., Wang S; The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, P. R. China. shunchunwang@126.com. |
| Abstrakt: |
Inhibition of glucose uptake in the intestine through sodium-dependent glucose transporter 1 (SGLT1) or glucose transporter 2 (GLUT2) may be beneficial in controlling postprandial blood glucose levels. Gallic acid and ten of its derivatives were identified in the active fractions of Terminalia chebula Retz. fructus immaturus, a popular edible plant fruit which has previously been associated with the inhibition of glucose uptake. Gallic acid derivatives (methyl gallate, ethyl gallate, pentyl gallate, 3,4,6-tri-O-galloyl-β-d-glucose, and corilagin) showed good glucose transport inhibition with inhibitory rates of 72.1 ± 1.6%, 71.5 ± 1.4%, 79.9 ± 1.2%, 44.7 ± 1.2%, and 75.0 ± 0.7% at 5 mM d-glucose and/or 56.3 ± 2.3, 52.1 ± 3.2%, 70.2 ± 1.7%, 15.6 ± 1.6%, and 37.1 ± 0.8% at 25 mM d-glucose. However, only 3,4,6-tri-O-galloyl-β-d-glucose and corilagin were confirmed GLUT2-specific inhibitors. Whilst some tea flavonoids demonstrated minimal glucose transport inhibition, their gallic acid derivatives strongly inhibited transport effect with GLUT2 specificity. This suggests that gallic acid structures are crucial for glucose transport inhibition. Plants, such as T. chebula, which contain high levels of gallic acid and its derivatives, show promise as natural functional ingredients for inclusion in foods and drinks designed to control postprandial glucose levels. |
