Effect of raw and encapsulated policosanol on lipid profiles, blood biochemistry, activity, energy expenditure and macronutrient metabolism of adult cats.

Autor:	Templeman JR; Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada., Hogan K; Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada., Blanchard A; Pancosma, Le Grand Saconnex, Switzerland., Marinangeli CP; Pulse Canada, Winnipeg, MB, Canada., Camara A; Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada., Verbrugghe A; Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada., Shoveller AK; Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada.
Jazyk:	angličtina
Zdroj:	Journal of feline medicine and surgery [J Feline Med Surg] 2022 Feb; Vol. 24 (2), pp. 177-184. Date of Electronic Publication: 2021 May 14.
DOI:	10.1177/1098612X211013738
Abstrakt:	Objectives: The objective of this study was to verify the safety of policosanol supplementation for domestic cats. The effects of raw and encapsulated policosanol were compared with positive (L-carnitine) and negative (no supplementation) controls on outcomes of complete blood count, serum biochemistry, energy expenditure, respiratory quotient and physical activity in healthy young adult cats. Methods: The study was a replicated 4 × 4 complete Latin square design. Eight cats (four castrated males, four spayed females; mean age 3.0 ± 1.0 years; mean weight 4.36 ± 1.08 kg; mean body condition score 5.4 ± 1.4) were blocked by sex and body weight then randomized to treatment groups: raw policosanol (10 mg/kg body weight), encapsulated policosanol (50 mg/kg body weight), L-carnitine (200 mg/kg body weight) or no supplementation. Treatments were supplemented to a basal diet for 28 days with a 1-week washout between periods. Food was distributed equally between two offerings to ensure complete supplement consumption (first offering) and measure consumption time (second offering). Blood collection (lipid profile, complete blood count, serum biochemistry) and indirect calorimetry (energy expenditure, respiratory quotient) were conducted at days 0, 14 and 28 of each period. Activity monitors were worn 7 days prior to indirect calorimetry and blood collection. Data were analyzed using a repeated measures mixed model (SAS, v.9.4). Results: Food intake and body weight were similar among treatments. There was no effect of treatment on lipid profile, serum biochemistry, activity, energy expenditure or respiratory quotient ( P >0.05); however, time to consume a second meal was greatest in cats fed raw policosanol ( P <0.05). Conclusions and Relevance: These data suggest that policosanol is safe for feline consumption. Further studies with cats demonstrating cardiometabolic risk factors are warranted to confirm whether policosanol therapy is an efficacious treatment for hyperlipidemia and obesity.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu