Long-term air pollution and road traffic noise exposure and COPD: the Danish Nurse Cohort.

Autor:	Liu S; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark., Lim YH; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark., Pedersen M; Section of Epidemiology, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark., Jørgensen JT; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark., Amini H; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.; Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Cole-Hunter T; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.; Centre for Air pollution, energy and health Research (CAR), University of Sydney, Sydney, Australia., Mehta AJ; Section of Epidemiology, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.; Statistics Denmark, Copenhagen, Denmark., So R; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark., Mortensen LH; Section of Epidemiology, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.; Statistics Denmark, Copenhagen, Denmark., Westendorp RGJ; Section of Epidemiology, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark.; Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., Loft S; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark., Bräuner EV; Dept of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Ketzel M; Dept of Environmental Science, Aarhus University, Roskilde, Denmark.; Global Centre for Clean Air Research (GCARE), University of Surrey, Guildford, UK., Hertel O; Dept of Bioscience, Aarhus University, Roskilde, Denmark.; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Roskilde, Denmark., Brandt J; Dept of Environmental Science, Aarhus University, Roskilde, Denmark.; iClimate, Aarhus University, Roskilde, Denmark., Jensen SS; Dept of Environmental Science, Aarhus University, Roskilde, Denmark., Christensen JH; Dept of Environmental Science, Aarhus University, Roskilde, Denmark., Sigsgaard T; Dept of Public Health, Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark., Geels C; Dept of Environmental Science, Aarhus University, Roskilde, Denmark., Frohn LM; Dept of Environmental Science, Aarhus University, Roskilde, Denmark., Brboric M; Dept of Environmental Engineering and Occupational Safety and Health, Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia., Radonic J; Dept of Environmental Engineering and Occupational Safety and Health, Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia., Turk Sekulic M; Dept of Environmental Engineering and Occupational Safety and Health, Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia., Bønnelykke K; COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Backalarz C; DELTA Acoustics, Hørsholm, Denmark., Simonsen MK; Diakonissestiftelsen, Frederiksberg, Denmark.; The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark., Andersen ZJ; Section of Environmental Health, Dept of Public Health, University of Copenhagen, Copenhagen, Denmark zorana.andersen@sund.ku.dk.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2021 Dec 02; Vol. 58 (6). Date of Electronic Publication: 2021 Dec 02 (Print Publication: 2021).
DOI:	10.1183/13993003.04594-2020
Abstrakt:	Background: While air pollution has been linked to the development of chronic obstructive pulmonary disease (COPD), evidence on the role of environmental noise is just emerging. We examined the associations of long-term exposure to air pollution and road traffic noise with COPD incidence. Methods: We defined COPD incidence for 24 538 female nurses from the Danish Nurse Cohort (age >44 years) as the first hospital contact between baseline (1993 or 1999) and 2015. We estimated residential annual mean concentrations of particulate matter with an aerodynamic diameter <2.5 µm (PM 2.5 ) since 1990 and nitrogen dioxide (NO 2 ) since 1970 using the Danish Eulerian Hemispheric Model/Urban Background Model/Air Geographic Information System modelling system, and road traffic noise (L den ) since 1970 using the Nord2000 model. Time-varying Cox regression models were applied to assess the associations of air pollution and road traffic noise with COPD incidence. Results: 977 nurses developed COPD during a mean of 18.6 years' follow-up. We observed associations with COPD for all three exposures with HRs and 95% CIs of 1.19 (1.01-1.41) per 6.26 µg·m -3 for PM 2.5 , 1.13 (1.05-1.20) per 8.19 µg·m -3 for NO 2 and 1.15 (1.06-1.25) per 10 dB for L den . Associations with NO 2 and L den attenuated slightly after mutual adjustment, but were robust to adjustment for PM 2.5 . Associations with PM 2.5 were attenuated to null after adjustment for either NO 2 or L den . No potential interaction effect was observed between air pollutants and noise. Conclusion: Long-term exposure to air pollution, especially traffic-related NO 2 , and to road traffic noise were independently associated with COPD. Competing Interests: Conflict of interest: S. Liu has nothing to disclose. Conflict of interest: Y-H. Lim has nothing to disclose. Conflict of interest: M. Pedersen has nothing to disclose. Conflict of interest: J.T. Jørgensen has nothing to disclose. Conflict of interest: H. Amini has nothing to disclose. Conflict of interest: T. Cole-Hunter has nothing to disclose. Conflict of interest: A.J. Mehta has nothing to disclose. Conflict of interest: R. So has nothing to disclose. Conflict of interest: L.H. Mortensen has nothing to disclose. Conflict of interest: R.G.J. Westendorp has nothing to disclose. Conflict of interest: S. Loft has nothing to disclose. Conflict of interest: E.V. Bräuner has nothing to disclose. Conflict of interest: M. Ketzel has nothing to disclose. Conflict of interest: O. Hertel has nothing to disclose. Conflict of interest: J. Brandt has nothing to disclose. Conflict of interest: S.S. Jensen has nothing to disclose. Conflict of interest: J.H. Christensen has nothing to disclose. Conflict of interest: T. Sigsgaard has nothing to disclose. Conflict of interest: C. Geels has nothing to disclose. Conflict of interest: L.M. Frohn has nothing to disclose. Conflict of interest: M. Brborić has nothing to disclose. Conflict of interest: J. Radonić has nothing to disclose. Conflict of interest: M. Turk Sekulic has nothing to disclose. Conflict of interest: K. Bønnelykke has nothing to disclose. Conflict of interest: C. Backalarz has nothing to disclose. Conflict of interest: M.K. Simonsen has nothing to disclose. Conflict of interest: Z.J. Andersen has nothing to disclose. (Copyright ©The authors 2021. For reproduction rights and permissions contact permissions@ersnet.org.)
Databáze:	MEDLINE
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