Circulating endotoxin and inflammation: associations with fitness, physical activity and the effect of a 6-month programme of cycling exercise during haemodialysis.

Autor:	March DS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Lai KB; Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China., Neal T; Affinity Biomarker Labs, Translation and Innovation Hub, Imperial College White City Campus, London, UK., Graham-Brown MPM; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Highton PJ; Diabetes Research Centre, University of Leicester, Leicester, UK., Churchward DR; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Young HML; University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK., Dungey M; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Stensel DJ; NIHR Leicester Biomedical Research Centre, Leicester, UK.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK., Smith AC; Department of Health Sciences, University of Leicester, Leicester, UK., Bishop NC; NIHR Leicester Biomedical Research Centre, Leicester, UK.; Department of Health Sciences, University of Leicester, Leicester, UK., Szeto CC; Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China., Burton JO; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Jazyk:	angličtina
Zdroj:	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2022 Jan 25; Vol. 37 (2), pp. 366-374.
DOI:	10.1093/ndt/gfab178
Abstrakt:	Background: Intradialytic cycling (IDC) may provide cardiovascular benefits to individuals receiving haemodialysis, but the exact mechanism behind these improvements remains unclear. The primary aim of this study was to investigate the effect of a 6-month programme of IDC on circulating endotoxin (secondary analysis from the CYCLE-HD trial). Secondary aims were to investigate changes in circulating cytokines [interleukin-6 (IL-6), IL-10, tumour necrosis factor-α, C-reactive protein (CRP) and the IL-6:IL-10 ratio] and their associations with physical activity, fitness and cardiovascular outcomes. Methods: Participants were randomized to either a 6-month programme of IDC (thrice weekly, moderate intensity cycling at a rating of perceived exertion of 12-14) in addition to usual care (n = 46) or usual care only (control group; n = 46). Outcome measures were obtained at baseline and then again at 6 months. Results: There was no significant (P = 0.137) difference in circulating endotoxin between groups at 6 months (IDC group: 0.34 ± 0.08 EU/mL; control group: 0.37 ± 0.07 EU/mL). There were no significant between-group differences in any circulating cytokine following the 6-month programme of IDC. Higher levels of physical activity and fitness were associated with lower levels of endotoxin, IL-6, CRP and IL-6:IL-10 ratio. Conclusions: Our data show no change in circulating endotoxin or cytokines following a 6-month programme of IDC. However, higher levels of physical activity outside of haemodialysis were associated with lower levels of inflammation. (© The Author(s) 2021. Published by Oxford University Press on behalf of the ERA.)
Databáze:	MEDLINE
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