Insulin resistance surrogates predict hypertension plus hyperuricemia.

Autor: Li Y; Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Department of Epidemiology and Public Health, Tongji University School of Medicine, Shanghai, China., You A; Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Department of Epidemiology and Public Health, Tongji University School of Medicine, Shanghai, China., Tomlinson B; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Faculty of Medicine, Macau University of Science and Technology, Taipa, Macau, China., Yue L; Anshun People's Hospital, Guizhou, China., Zhao K; Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Department of Epidemiology and Public Health, Tongji University School of Medicine, Shanghai, China., Fan H; Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China., Zheng L; Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Jazyk: angličtina
Zdroj: Journal of diabetes investigation [J Diabetes Investig] 2021 Nov; Vol. 12 (11), pp. 2046-2053. Date of Electronic Publication: 2021 Jun 06.
DOI: 10.1111/jdi.13573
Abstrakt: Aims/introduction: To compare the association of hypertension plus hyperuricemia with four insulin resistance surrogates, including glucose and triglycerides (TyG index), TyG index with body mass index (TyG-BMI), the ratio of triglycerides divided by high-density lipoprotein cholesterol (TG/HDL-C) and metabolic score for insulin resistance (METS-IR).
Materials and Methods: Data from a cross-sectional epidemiological study enrolling a representative population sample aged ≥65 years were used to calculate the four indexes. The association with hypertension plus hyperuricemia and insulin resistance surrogates was examined with multivariate logistic regression and receiver operating characteristic.
Results: A total of 4,352 participants were included, including 93 (2.1%) patients with hyperuricemia alone, 2,875 (66.1%) with hypertension alone and 587 (13.5%) with hypertension plus hyperuricemia. Mutivariate logistic regression showed that TyG index, TyG-BMI, TG/HDL-C and METS-IR were all significantly correlated with hyperuricemia, hypertension and hypertension plus hyperuricemia. Compared with the lowest quartile, the odds ratios (OR) of the highest quartile of the four indicators for hypertension plus hyperuricemia were TyG index: OR 6.39 (95% confidence interval [CI] 4.17-9.78); TyG-BMI: OR 8.54 (95% CI 5.58-13.09); TG/HDL-C: OR 7.21 (95% CI 4.72-11.01); METS-IR: OR 9.30 (95% CI 6.00-14.43), respectively. TyG-BMI and METS-IR had moderate discriminative abilities for hypertension plus hyperuricemia and the AUC values were 0.72 (95% CI 0.70-0.74) and 0.73 (95% CI 0.70-0.75).
Conclusions: The present study suggested that TyG index, TyG-BMI, TG/HDL-C and METS-IR had a significant correlation with hypertension plus hyperuricemia, and TyG-BMI and METS-IR had discriminative abilities for hypertension plus hyperuricemia.
(© 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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