Maternal Glycemia During Pregnancy and Early Offspring Development: A Prospective Birth Cohort Study.

Autor:	Wang P; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China., Xie J; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China., Jiao XC; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Ma SS; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Liu Y; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Yin WJ; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China., Tao RX; Department of Obstetrics and Gynecology, the First People's Hospital of Hefei City, Hefei, China., Hu HL; Department of endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Zhang Y; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Chen XX; Department of Obstetrics and Gynecology, Anhui Women and Child Health Care Hospital, Hefei, China., Tao FB; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China.; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, China., Zhu P; Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.; MOE Key Laboratory of Population Health Across Life Cycle, Hefei, China.; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, China.; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, China.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Jul 13; Vol. 106 (8), pp. 2279-2290.
DOI:	10.1210/clinem/dgab331
Abstrakt:	Context: The association of maternal gestational diabetes mellitus (GDM) with neurodevelopmental outcomes remains controversial and evidence that maternal increasing levels of glucose during pregnancy associated with the risk for impaired neurodevelopment were limited. Objective: To identify the continuous association of increasing maternal glucose levels with neurodevelopmental disorders in offspring and explore the potential contribution of cord metabolites to this association. Methods: The prospective birth cohort study included 1036 mother-child pairs. Primary predictors were maternal exposure GDM and maternal glucose values at a 75-g oral-glucose-tolerance test at 24 to 28 weeks during pregnancy. Primary neurodevelopmental outcomes at 12 months in offspring were assessed by the Ages and Stages Questionnaires, Third Edition (ASQ-3). Results: Maternal GDM was associated with failing the communication domain in offspring in the adjusted models [relative risk (RR) with 95% CI: 1.97 (1.11, 3.52)]. Increasing levels of fasting plasma glucose (FPG), 1-h plasma glucose (1-h PG) and 2-h plasma glucose (2-h PG) with 1 SD change were at higher risks in failing the personal social domain of ASQ-3 [RRs with 95% CI for FPG: 1.49 (1.09, 2.04); for 1-h PG: 1.70 (1.27, 2.29); for 2-h PG: 1.36 (1.01, 1.84)]. The linear association was also demonstrated. Compared with girls, boys exposed to higher maternal glucose levels were inclined to the failure of the personal social domain. Mediation analysis showed the contribution of maternal GDM to failure of communication domain mediated by C-peptide. Conclusions: Maternal glucose levels below those diagnostic of diabetes are continuously associated with impaired neurodevelopment in offspring at 12 months. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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