A Functional Adenosine Deaminase Polymorphism Associates with Evening Melatonin Levels and Sleep Quality.

Autor: Tartar JL; Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL, USA., Hiffernan FS; Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL, USA., Freitas KE; Department of Clinical Psychology, Nova Southeastern University, Ft. Lauderdale, FL, USA., Fins AI; Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL, USA., Banks JB; Department of Psychology and Neuroscience, Nova Southeastern University, Ft. Lauderdale, FL, USA.
Jazyk: angličtina
Zdroj: Journal of circadian rhythms [J Circadian Rhythms] 2021 Apr 28; Vol. 19, pp. 5. Date of Electronic Publication: 2021 Apr 28.
DOI: 10.5334/jcr.209
Abstrakt: Increased adenosine levels throughout the day promote sleepiness. A single nucleotide polymorphism (SNP) in the adenosine deaminase ADA gene (rs73598374) has been shown to affect sleep regulation. The extent to which lower ADA enzymatic activity is associated with the homeostatic sleep factor, melatonin, is uncertain. To test this possibility, we assessed the relationship between the ADA polymorphism and evening melatonin levels, as well as self-reported sleep behavior. Given the close relationship between mood and sleep behavior, we further tested the impact of ADA genotype on self-reported mood. We show that relative to the GG homozygotes, the A allele carriers (higher adenosine levels) had significantly higher evening melatonin levels as well as significantly better sleep quality. We further show the correlations between sleep and mood measures were altered by ADA genotype, with a stronger relationship observed in the GG (lower adenosine) group. Combined, these findings advance our understanding of the biochemistry of melatonin production by showing that there is a relationship between ADA genotype and melatonin levels. The differential relationships between sleep and psychological health between the genotype groups may reveal novel insights about the development of genotype-specific progression of various psychological disorders such as chronic anxiety and stress.
Competing Interests: The authors have no competing interests to declare.
(Copyright: © 2021 The Author(s).)
Databáze: MEDLINE
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