Functional interferometric diffusing wave spectroscopy of the human brain.

Autor:	Zhou W; Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA., Kholiqov O; Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA., Zhu J; Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA., Zhao M; Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA., Zimmermann LL; Department of Neurological Surgery, University of California, Davis, Sacramento, CA, USA., Martin RM; Department of Neurological Surgery, University of California, Davis, Sacramento, CA, USA., Lyeth BG; Department of Neurological Surgery, University of California, Davis, Sacramento, CA, USA., Srinivasan VJ; Department of Biomedical Engineering, University of California, Davis, Davis, CA, USA. vjsriniv@ucdavis.edu.; Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, CA, USA.; Department of Ophthalmology, NYU Langone Health, New York, NY, USA.; Department of Radiology, NYU Langone Health, New York, NY, USA.; Tech4Health Institute, NYU Langone Health, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2021 May 12; Vol. 7 (20). Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).
DOI:	10.1126/sciadv.abe0150
Abstrakt:	Cerebral blood flow (CBF) is essential for brain function, and CBF-related signals can inform us about brain activity. Yet currently, high-end medical instrumentation is needed to perform a CBF measurement in adult humans. Here, we describe functional interferometric diffusing wave spectroscopy (fiDWS), which introduces and collects near-infrared light via the scalp, using inexpensive detector arrays to rapidly monitor coherent light fluctuations that encode brain blood flow index (BFI), a surrogate for CBF. Compared to other functional optical approaches, fiDWS measures BFI faster and deeper while also providing continuous wave absorption signals. Achieving clear pulsatile BFI waveforms at source-collector separations of 3.5 cm, we confirm that optical BFI, not absorption, shows a graded hypercapnic response consistent with human cerebrovascular physiology, and that BFI has a better contrast-to-noise ratio than absorption during brain activation. By providing high-throughput measurements of optical BFI at low cost, fiDWS will expand access to CBF. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Databáze:	MEDLINE
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