Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma: An International Multi-Institutional Analysis.

Autor:	Schulte JJ; Department of Pathology, University of Chicago, Chicago, IL, USA.; Department of Pathology and Lab Medicine, University of Wisconsin, Madison, WI, USA., Chapel DB; Department of Pathology, University of Chicago, Chicago, IL, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Attanoos R; Department of Cellular Pathology, University Hospital of Wales and School of Medicine, Cardiff University, Cardiff, UK., Brcic L; Diagnostics and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Burn J; Douglass Hanly Moir Pathology, Sydney, Australia., Butnor KJ; Department of Pathology, University of Vermont Medical Center, Burlington, VT, USA., Chang N; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada., Chen H; Department of Pathology, University of Chicago, Chicago, IL, USA., Dacic S; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., De Perrot M; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada., Fukuoka J; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Galateau-Salle F; Department of Pathology, MESOPATH-MESOBANK, Centre León Bérard, Lyon, France., Godschachner T; Diagnostics and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Hiroshima K; Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo, Japan., Klebe S; Department of Anatomical Pathology, SA Pathology, Flinders University, Adelaide, Australia., Krausz T; Department of Pathology, University of Chicago, Chicago, IL, USA., Litzky L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Marchevsky AM; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Mueller J; Department of Pathology, University of Chicago, Chicago, IL, USA., Nabeshima K; Department of Pathology, Fukuoka University Hospital, Fukuoka, Japan., Nicholson AG; Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK., Pal P; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada., Roden AC; Department of Laboratory Medicine and Pathology; Mayo Clinic, Rochester, MN, USA., Rorvig S; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Santoni-Rugiu E; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Tazelaar H; Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA., Tsao MS; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada., Walts AE; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Weynand B; Department of Pathology, Universitair Ziekenhuis Leuven, Leuven, Belgium., Zaizen Y; Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Zhang YZ; Department of Histopathology, Royal Brompton and Harefield NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, UK., Husain AN; Department of Pathology, University of Chicago, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	American journal of clinical pathology [Am J Clin Pathol] 2021 Nov 08; Vol. 156 (6), pp. 989-999.
DOI:	10.1093/ajcp/aqab054
Abstrakt:	Objectives: Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy and resection specimens of pleural MM. Methods: Histologic subtype, percentage of epithelioid morphology, nuclear grade, and the presence or absence of necrosis were compared in 429 paired biopsies and resection specimens of pleural MM from 19 institutions. Results: Histologic subtype was concordant in 81% of cases (κ = 0.58). When compared with resection specimens, epithelioid morphology at biopsy had a positive predictive value (PPV) of 78.9% and a negative predictive value (NPV) of 93.5%; sarcomatoid morphology showed high PPV (92.9%) and NPV (99.3%), and biphasic morphology PPV was 89.7% and NPV was 79.7%. Agreement of the percentage of epithelioid morphology was fair (κ = 0.27). Nuclear grade and necrosis were concordant in 75% (κ = 0.59) and 81% (κ = 0.53) of cases, respectively. Nuclear grade showed moderate (κ = 0.53) and substantial (κ = 0.67) agreement from patients with and without neoadjuvant therapy, respectively, and necrosis showed moderate (κ = 0.47 and κ = 0.60) agreement, respectively, in the same subsets of paired specimens. Conclusions: Paired biopsy-resection specimens from pleural MM show overall moderate agreement in pathologic parameters. These findings may help guide postbiopsy management and triage of patients with MM. (© American Society for Clinical Pathology, 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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